Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4522	KCC-07 CAS No.315702-75-1	KCC-07/CAS No.315702-75-1 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity.	price>
R-R-4523	Duocarmycin DM free base CAS No.1116745-06-2	Duocarmycin DM free base/CAS No.1116745-06-2, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.	price>
R-R-4524	Melflufen hydrochloride CAS No.380449-54-7	Melflufen (Melphalan flufenamide) hydrochloride/CAS No.380449-54-7, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells.	price>
R-R-4525	Treosulfan CAS No.299-75-2	Treosulfan (NSC 39069)/CAS No.299-75-2 is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types.	price>
R-R-4526	OBI-3424 CAS No.2097713-68-1	OBI-3424 (TH-3424)/CAS No.2097713-68-1 is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research.	price>
R-R-4527	Illudin S CAS No.1149-99-1	Illudin S/CAS No.1149-99-1, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells.	price>
R-R-4528	PIP-199 CAS No.622795-76-0	PIP-199/CAS No.622795-76-0 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics.	price>
R-R-4529	Tretazicar CAS No.21919-05-1	Tretazicar (CB 1954)/CAS No.21919-05-1, an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1).	price>
R-R-4530	SG2057 CAS No.260417-62-7	SG2057 (DRG16)/CAS No.260417-62-7 is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent.	price>
R-R-4531	Nimustine hydrochloride CAS No.55661-38-6	Nimustine hydrochloride (ACNU)/CAS No.55661-38-6 is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas.	price>

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