Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4511	Phosphoramide mustard cyclohexanamine CAS No.1566-15-0	Phosphoramide mustard cyclohexanamine/CAS No.1566-15-0 is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage.	price>
R-R-4512	Calicheamicin CAS No.108212-75-5	Calicheamicin/CAS No.108212-75-5, an antitumor antibiotic, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor. Calicheamicin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-4513	Lurbinectedin CAS No.497871-47-3	Lurbinectedin (PM01183)/CAS No.497871-47-3 is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.	price>
R-R-4514	SG3199 CAS No.1595275-71-0	SG3199/CAS No.1595275-71-0 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).	price>
R-R-4515	Tesirine CAS No.1595275-62-9	Tesirine (SG3249)/CAS No.1595275-62-9 is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity.	price>
R-R-4516	Lomustine CAS No.13010-47-4	Lomustine (CCNU; NSC 79037)/CAS No.13010-47-4 is a DNA alkylating agent, with antitumor activity.	price>
R-R-4517	Procarbazine Hydrochloride CAS No.366-70-1	Procarbazine Hydrochloride/CAS No.366-70-1 is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin disease research.	price>
R-R-4519	SJG-136 CAS No.232931-57-6	SJG-136/CAS No.232931-57-6 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.	price>
R-R-4520	Duocarmycin TM CAS No.157922-77-5	Duocarmycin TM (CBI-TMI)/CAS No.157922-77-5 is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.	price>
R-R-4521	Trioxsalen CAS No.3902-71-4	Trioxsalen (Trisoralen)/CAS No.3902-71-4, a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation.	price>

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