Product apis-autophagy

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Catalog	name	Description	price
R-R-2171	6-CEPN CAS No.1054549-73-3	6-CEPN/CAS No.1054549-73-3 is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase).	price>
R-R-2172	ATG7-IN-3 CAS No.2226229-76-9	ATG7-IN-3 (compound 18)/CAS No.2226229-76-9 is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4.	price>
R-R-2173	CC214-2 CAS No.1228012-18-7	CC214-2/CAS No.1228012-18-7 is an oral active and selective mTOR kinase inhibitor. CC214-2 targets to both of mTORC1 (pS6) and mTORC2 (pAktS473). CC214-2 induces autophagy, which is a potential target for host-directed therapy (HDT) in tuberculosis. CC214-2 exhibits synergistic bactericidal and sterilizing activity agasinst tuberculosis (TB), and shortens the treatment duration. CC214-2 also inhibits Rapamycin (HY-10219)-resistant signaling and the growth of glioblastomas in vitro and in vivo.	price>
R-R-2174	ICCB-19 hydrochloride CAS No.1803605-68-6	ICCB-19 hydrochloride/CAS No.1803605-68-6 is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins.	price>
R-R-2175	20-Deoxyingenol CAS No.54706-99-9	20-Deoxyingenol/CAS No.54706-99-9, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).	price>
R-R-2176	Atg4B-IN-2 CAS No.2765008-88-4	Atg4B-IN-2/CAS No.2765008-88-4 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.	price>
R-R-2177	P62-mediated mitophagy inducer CAS No.1809031-84-2	P62-mediated mitophagy inducer (PMI)/CAS No.1809031-84-2 is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.	price>
R-R-2178	HDAC10-IN-1	HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-R-2179	HDAC10-IN-2 hydrochloride	HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-R-2180	Daurisoline CAS No.70553-76-3	Daurisoline/CAS No.70553-76-3 is a hERG inhibitor and also an autophagy blocker.	price>

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