Product apis-autophagy

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Catalog	name	Description	price
R-R-2151	Forskolin CAS No.66575-29-9	Forskolin (Coleonol)/CAS No.66575-29-9 is a potent activator of adenylate cyclase with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces the differentiation of various cell types and activates the pregnane X receptors (PXR) and FXR. Forskolin exerts an inotropic effect on the heart and has antiplatelet and antihypertensive actions. Forskolin also induces autophagy.	price>
R-R-2152	Trimetazidine CAS No.5011-34-7	Trimetazidine/CAS No.5011-34-7 is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-R-2153	Trimetazidine dihydrochloride CAS No.13171-25-0	Trimetazidine dihydrochloride/CAS No.13171-25-0 is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-R-2154	Gefitinib-d6 CAS No.1228664-49-0	Gefitinib-d6/CAS No.1228664-49-0 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.	price>
R-R-2155	Liensinine Diperchlorate CAS No.5088-90-4	Liensinine Diperchlorate/CAS No.5088-90-4 is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.	price>
R-R-2156	Chloroquine-d5 CAS No.1854126-41-2	Chloroquine-d5/CAS No.1854126-41-2 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).	price>
R-R-2157	RSVA405 CAS No.140405-36-3	RSVA405/CAS No.140405-36-3 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity.	price>
R-R-2158	Crustecdysone CAS No.5289-74-7	Crustecdysone (20-Hydroxyecdysone)/CAS No.5289-74-7 is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).	price>
R-R-2159	Autophagy inducer 3 CAS No.2691054-63-2	Autophagy inducer 3/CAS No.2691054-63-2 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins.	price>
R-R-2160	AUTEN-67 CAS No.1783800-77-0	AUTEN-67 (Autophagy enhancer-67)/CAS No.1783800-77-0 is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease.	price>

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