Product apis-autophagy

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Catalog	name	Description	price
R-R-2161	Vps34-IN-4 CAS No.1383716-46-8	Vps34-IN-4 (compound 19)/CAS No.1383716-46-8 is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components.	price>
R-R-2162	mTOR inhibitor-8 CAS No.2489196-70-3	mTOR inhibitor-8/CAS No.2489196-70-3 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.	price>
R-R-2163	Rapamycin-d3 CAS No.392711-19-2	Rapamycin-d3/CAS No.392711-19-2 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	price>
R-R-2164	Corynoxine CAS No.6877-32-3	Corynoxine/CAS No.6877-32-3, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway.	price>
R-R-2165	ATG7-IN-2 CAS No.2226227-75-2	ATG7-IN-2 (compound 1)/CAS No.2226227-75-2 is a potent ATG7 inhibitor, with an IC50 of 0.089 μM. ATG7-IN-2 inhibits autophagy marker LC3B.	price>
R-R-2166	GPP78 CAS No.1202580-59-3	GPP78 (CAY10618)/CAS No.1202580-59-3 is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.	price>
R-R-2167	MRT67307 CAS No.1190378-57-4	MRT67307/CAS No.1190378-57-4 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.	price>
R-R-2168	EN6 CAS No.1808714-73-9	EN6/CAS No.1808714-73-9 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner.	price>
R-R-2169	S29434 CAS No.874484-20-5	S29434 (NMDPEF)/CAS No.874484-20-5 is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production.	price>
R-R-2170	SBP-7455 CAS No.1884222-74-5	SBP-7455/CAS No.1884222-74-5 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research.	price>

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