Product apis-apoptosis

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Catalog	name	Description	price
R-C-571	Tenovin-1 cas:380315-80-0	Tenovin-1,a p53 activator,protects p53 from MDM2-mediated degradation.Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase(DHODH)inhibitor.	price>
R-C-572	Apoptosis Activator 2 cas:79183-19-0	Apoptosis Activator 2 strongly induces caspase-3 activation,PARP cleavage,and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM,inactive to HMEC,PREC,or MCF-10A cells.	price>
R-C-573	HA14-1 cas:65673-63-4	HA14-1 is a small,cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action.HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.	price>
R-C-594	ABT-199 cas:1257044-40-8	Venetoclax (ABT-199,GDC-0199)is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays,4800-fold more selective versus Bcl-xL and Bcl-w,and no activity to Mcl-1.Venetoclax is reported to induce cell growth suppression,apoptosis,cell cycle arrest,and autophagy in triple negative breast cancer MDA-MB-231 cells.	price>
R-C-715	Birinapant cas:1260251-31-7	Birinapant,also known as TL32711,is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases(SMAC) and inhibitor of IAP(Inhibitor of Apoptosis Protein)family proteins,with potential antineoplastic activity.	price>
R-C-724	JNJ-26854165 (Serdemetan) CAS:881202-45-5	Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells,inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.	price>
R-C-763	DAPT (GSI-IX, LY-374973) cas:208255-80-5	DAPT(GSI-IX,LY-374973)is a novel γ-secretase inhibitor,which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.	price>
R-C-974	Obatoclax mesylate cas:803712-79-0	Obatoclax Mesylate is the mesylate salt of obatoclax,a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities.Obatoclax binds to members of the Bcl-2 protein family,preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells.The Bcl-2 family of proteins(bcl-2,bcl-xl, bcl-w,and Mcl-1)are overexpressed in a wide variety of cancers,including those of the lymphatic system,breast,lung,prostate,and colon.	price>
R-C-993	WK23	WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX,its median inhibitory concentration(IC50) values to MDM2/MDMX are 1.17 and 36 uM,respectively.	price>
R-C-995	CID755673 cas:521937-07-5	CID755673 is a potent PKD inhibitor with IC50s of 182 nM,280 nM and 227 nM for PKD1,PKD2 and PKD3,respectively.	price>

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