Product apis-apoptosis

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Catalog	name	Description	price
R-C-1040	MX1013 CAS NO. 582316-00-5	MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1,caspase-3, and caspase-6,7,8,and 9.	price>
R-C-1084	LCL161 CAS:1005342-46-0	LCL161 enhanced the pro apoptotic effect of nilotinib and PKC412 on leukemia in vitro,and enhanced the activity of two kinase inhibitors on leukemia in vivo.In addition,LCL161 synergized with nilotinib in vivo and significantly reduced the burden of leukemia to below the baseline level of inhibition of medium and high dose nilotinib.Finally,LCL161 showed antiproliferative effect on the cells with inherent resistance to tyrosine kinase inhibitors,which was the result of the mutant expression of the compound inhibitory protein target.LCL161 is a small molecule antagonist of apoptosis inhibitor(IAP),with IC50 value of 10.23 μM.lcl161 in Hep3B cells could inhibit the proliferation and activity of Hep3B and PLC5 cells.Lcl161 also had effect on ALCL cell line karpas-299 with IC50 value of 1.6μM.	price>
R-C-1193	Kevetrin HCl	Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53,with potential antineoplastic activity.	price>
R-C-1230	SAR405838 (MI-773) CAS:1303607-60-4	SAR405838 is a highly potent and selective MDM2 inhibitor,binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins.	price>
R-C-2239	Oroxin B CAS：114482-86-9	Oroxin B(OB)is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.)Vent.Oroxin B(OB)possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN,down regulation of COX-2,VEGF,PI3K,and p-AKT.	price>
R-C-1254	CCT007093 CAS：176957-55-4	CCT007093 is an effective protein phosphatase 1D(PPM1D Wip1)inhibitor.Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.	price>
R-C-1272	NVP-231 CAS：362003-83-6	NVP-231 is a potent,specific,and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide,resulting in decreased endogenous C1P levels.When combined with another ceramide metabolizing inhibitor,such as tamoxifen,NVP-231 synergistically increased ceramide levels and reduced cell growth.Therefore.NVP-231 represents a novel and promising compound for controlling ceramide metabolism that may provide insight into CerK physiological function.	price>
R-C-1311	umi-77 CAS ：518303-20-3	UMI-77 is a selective Mcl-1 inhibitor,which shows high binding affinity to Mcl-1(IC50=0.31μM).UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM,showing selectivity over other members of anti-apoptotic Bcl-2 members.	price>
R-C-1323	NSC59984 CAS：803647-40-7	NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells,with EC50 of 8.38 uM for p53-null HCT116 cells.	price>
R-C-1366	NQDI-1 CAS：175026-96-7	NQDI-1 is an inhibitor of ASK1,which attenuates acute ischemic renal injury by modulating oxidative stress and cell death.NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages Apoptosis signal-regulating kinase 1(ASK1)is among the signaling events that lead to postischemic cell death.Inhibition of ASK1 pathway protected hearts from ischemic damage.	price>

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