Product apis-apoptosis

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Catalog	name	Description	price
R-R-2117	Resistomycin CAS No.20004-62-0	Resistomycin/CAS No.20004-62-0, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.	price>
R-R-2118	UCM-1336 CAS No.1621535-90-7	UCM-1336/CAS No.1621535-90-7 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis.	price>
R-R-2119	Taraxerol acetate CAS No.2189-80-2	Taraxerol acetate/CAS No.2189-80-2 is a COX-1 and COX-2 inhibitor with IC50 values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis.	price>
R-R-2120	MG-115 CAS No.133407-86-0	MG-115/CAS No.133407-86-0 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.	price>
R-C-437	Telaprevir (VX-950)	Trapivir is an effective and selective reversible HCV NS3-4A protein inhibitor, which acts on NS3 protease domain and NS4A cofactor peptide of genotype 1(strain h).Vx-950 is an effective and selective peptide like inhibitor of hepatitis C virus NS3-4A serine protease.It shows excellent antiviral activity in both type 1b HCV replicon cells (50% inhibition concentration [IC50]=354nm) and human fetal liver cells(IC50=280nm) infected with sera from type 1A HCV positive patients.	price>
R-C-471	Tasisulam(LY573636) CAS:519055-63-1	LY573636 is a potent anti-tumor agent,which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo.LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.	price>
R-C-482	ABT-263(Navitoclax) CAS:923564-51-6	ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki of <1 nmol/L for Bcl-2,Bcl-xL,and Bcl-w).it maintains a high affinity for Bcl-xL,Bcl-2,and Bcl-w,(Ki ≤1 nmol/L),but binds more weakly to Mcl-1 and A1.	price>
R-C-483	ABT-737 cas:852808-04-9	ABT-737 is a pan-Bcl-2 inhibitor.IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10μM (Nalm-6,K562 and HL-60).	price>
R-C-531	AT-406 cas:1071992-99-8	AT406(SM-406,ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM,1.9 nM,and 5.1 nM,50-to 100-fold higher affinities than the Smac AVPI peptide.	price>
R-C-564	RITA (NSC 652287) cas:213261-59-7	RITA(NSC 652287)induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks,and also inhibits MDM2-p53 interaction by targeting p53.	price>

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