Product apis-apoptosis

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Catalog	name	Description	price
R-C-1375	Idasanutlin (RG-7388) CAS：1229705-06-9	Idasanutlin,also known as RG7388 and RO5503781,is a highly potent and selective MDM2 antagonist with potential anticancer activity.RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53.By preventing the MDM2-p53 interaction,p53 is not enzymatically degraded and the transcriptional activity of p53 is restored.	price>
R-C-1390	Nutlin-3 CAS：890090-75-2	Nutlin-3,also known as(±)-Nutlin-3 and N-6287,is a p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment.Nutlin-3 specifically targets p53-Mdm2 interaction offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the restoration of the p53-mediated tumor suppression pathway while producing minimal cytotoxicity and side effects. Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells.Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.	price>
R-C-1502	ML281 CAS:1404437-62-2	ML-281 is a potent ans selective STK33 inhibitor(IC50=14 nM).ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors.ML281 is a valuable addition to small-molecule probes of STK33.v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors.STK33 was selectively toxic to KRAS-dependent cancer cell lines,suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.	price>
R-C-1513	Tenovin-6 CAS：1011557-82-6	Tenovin-6 is a analog of tenovin-1.Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1,SIRT2,and SIRT3 in vitro with IC50 values of 21,10,and 67uM,respectively.	price>
R-C-1566	Selonsertib (GS-4997) CAS：1448428-04-3	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1(ASK1),with potential anti-inflammatory,antineoplastic and anti-fibrotic activities.	price>
R-C-1568	Navitoclax (ABT-263) CAS：923564-51-6	Navitoclax(ABT-263)is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins,such as Bcl-xL,Bcl-2 and Bcl-w,with a Ki of less than 1nM.	price>
R-C-1575	QVD-oph CAS：1135695-98-5	Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties;inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1,3,8,9,10,and 12.Q-VD-OPh can inhibits HIV infection.Q-VD-OPh is able to cross the blood-brain barrier.	price>
R-C-1617	GW4869 CAS:6823-69-4	GW4869(GW69A,GW554869A)is a neutral,noncompetitive inhibitor of sphingomyelinase (SMase)with an IC50 of 1μM.It is selective for N-SMase,and does not inhibit acid SMase at up to at least 15μM.	price>
R-C-1647	Importazole CAS:662163-81-7	Importazole is a small molecule inhibitor of the transport receptor importin-β (Karyopherin beta)specifically blocking importin-β-mediated nuclear import. Importazole induces apoptosis and inhibits tumor growth.	price>
R-C-1665	NSC303580 CAS：64984-31-2	Pifithrin-μ(NSC 303580,PFTμ,2-Phenylethynesulfonamide)is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2,and also inhibits HSP70 function and autophagy.	price>

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