Product apis-apoptosis

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Catalog	name	Description	price
R-C-1667	TPEN CAS：16858-02-9	TPEN is a heavy metal chelator.Reacts with both Zn-proteome and Zn-metallothionein(MT)in LLC-PK1 cells;acts as an intracellular chelator of proteomic Zn2+.	price>
R-C-1755	AZD5582 CAS：1258392-53-8	AZD5582 is an antagonist of the inhibitor of apoptosis proteins(IAPs),which binds to the BIR3 domains cIAP1,cIAP2,and XIAP with IC50s of 15,21,and 15 nM, respectively.	price>
R-C-1759	GSK872 CAS：1346546-69-7	GSK872 is a receptor-interacting protein kinase-3(RIP3)inhibitor.GSK872 inhibits TNF-and virus-induced necrosis in 3T3-SA fibroblasts.It also inhibits necrosis induced by toll-like receptor 3(TLR3).	price>
R-C-1813	MSDC-0160(CAY10415) CAS:146062-49-9	MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer is disease.	price>
R-C-1875	BAM7 CAS:331244-89-4	BAM7 is a direct and selective activator of proapoptotic BAX with an IC50 of 3.3μM.	price>
R-C-1876	BTSA 1 CAS:314761-14-3	BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.	price>
R-C-2251	Resibufogenin CAS：465-39-4	Resibufogenin(Bufogenin,Recibufogenin),a component of huachansu with anticancer effect,triggers necroptosis through upregulating receptor-interacting protein kinase 3(RIP3)and phosphorylating mixed lineage kinase domain-like protein at Ser358.Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species(ROS)accumulation.Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity.	price>
R-C-1912	SM164 CAS：957135-43-2	SM-164 is a potent,non-peptide,cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39nM.SM-164 induces apoptosis and tumor regression.	price>
R-C-1917	Pralsetinib (BLU-667) CAS:2097132-94-8	Pralsetinib(BLU-667,CS 3009,Gavreto)is a highly potent and selective RET (c-RET)inhibitor with an IC50 of 0.4 nM for WT RET.It also demonstrates potent activity(IC50 0.4 nmol/L)against common oncogenic RET alterations,including RET(M918T).	price>
R-C-1924	S63845 CAS：1799633-27-4	S63845 is a potent and selective myeloid cell leukemia 1(MCL1)inhibitor with a Kd of 0.19nM for human MCL1.	price>

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