Product apis-apoptosis

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Catalog	name	Description	price
R-C-2127	BBT594 CAS：882405-89-2	BBT594(NVP-BBT594)is potent and selective RET and JAK2 inhibitor.NVP-BBT594 impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells.NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment.GDNF-RET signaling as a rational therapeutic target may be useful to combat or delay the onset of AI resistance in breast cancer.	price>
R-C-2131	Eprenetapopt (APR-246) CAS： 5291-32-7	Eprenetapopt(APR-246)is a first-in-class,small molecule that restores wild-type p53 functions in TP53-mutant cells.Eprenetapopt triggers apoptosis in tumor cells.Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1),a key regulator of cellular redox balance.	price>
R-C-2138	VLX600 CAS：327031-55-0	VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS),potentiates the effect of radiation in tumor spheroids in a synergistic manner.VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation.VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.	price>
R-C-2153	UCB-9260 CAS:1515888-53-5	UCB-9260,an orally active compound,inhibits TNF signaling by stabilising an asymmetric form of the trimer.UCB-9260 is selective for TNF over other superfamily members,and binds TNF with a similar Kd of 13nM.	price>
R-C-2163	Linderalactone CAS:728-61-0	Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins(Bax and Bcl-2)with an IC50 of 15µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway.	price>
R-C-2219	BMS-1001 CAS: 2113650-03-4	BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253nM.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.	price>
R-C-2222	Marinopyrrole A (Maritoclax) CAS:1227962-62-0	Marinopyrrole A(Maritoclax)is a selective Mcl-1 antagonist.It binds to Mcl-1,but not Bcl-XL,and targets Mcl-1 for proteasomal degradation.Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1μM.	price>
R-C-2223	Obatoclax Mesylate (GX15-070) CAS: 803712-79-0	Obatoclax Mesylate(GX15-070 Mesylate),a BH3 mimetic,is a pan-BCL-2 family proteins inhibitor with a Ki of 220nM for BCL-2.Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation.Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity.	price>
R-C-2224	Ethyl gallate CAS:831-61-8	Ethyl gallat(Phyllemblin,gallic acid ethyl ester),which could be found naturally in a variety of plant sources,is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8,-9,and -3 and the Bcl-2 interacting domain(Bid).	price>
R-C-2285	Xevinapant (AT406) CAS:1071992-99-8	Xevinapant(AT406,ARRY-334543,Debio1143,SM-406)is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4nM,1.9 nM,and 5.1nM,50-to 100-fold higher affinities than the Smac AVPI peptide.	price>

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