Product apis-apoptosis

Home > products > apis> apoptosis

Catalog	name	Description	price
R-C-2290	NSC 207895 CAS:58131-57-0	NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7,LNCaP,and A549 cells(1 to 10µM for 16 to 24h)by suppressesing MDMX promoter transcription activity(IC50=2.5µM in HT1080 cells),leading to enhanced p53 stabilization and activation.	price>
R-C-2498	Belnacasan (VX-765) CAS：273404-37-8	Belnacasan(VX-765)is an orally bioactive prodrug of VRT-043198,which is a potent and selective inhibitor of IL-converting enzyme(ICE)/caspase-1 with Kis of 0.8nM and less than 0.6nM for caspase-1 and caspase-4,respectively.Belnacasan (VX-765)inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7μM.	price>
R-C-2565	MDK83190 CAS：79183-19-0	MDK83190 is a potent apoptosis activator,induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner.	price>
R-C-2575	Sabutoclax CAS:1228108-65-3	Sabutoclax(BI-97C1)is a potent a Mcl-1 Antagonist.Sabutoclax inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer. Sabutoclax(BI97C1)induce mitochondrial fragmentation either upstream of or independent of apoptosis.	price>
R-C-2576	NVP-CGM097 CAS:1313363-54-0	NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3nM for hMDM2 in TR-FRET assay.It binds to the p53 binding-site of the Mdm2 protein,disrupting the interaction between both proteins,leading to an activation of the p53 pathway.	price>
R-C-2577	Navtemadlin (AMG 232) CAS:1352066-68-2	Navtemadlin(AMG 232)is a potent,selective and orally available inhibitor of p53-MDM2 interaction,with an IC50 of 0.6nM.Navtemadlin binds to MDM2 with a Kd of 0.045nM.	price>
R-C-2579	YH239-EE CAS:1364488-67-4	YH239-EE,ethyl ester of the free carboxylic acid compound YH239,is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.	price>
R-C-2580	BM-1074 CAS:1391108-10-3	BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete,and durable tumor regression in vivo.	price>
R-C-2582	WEHI-539 CAS:1431866-33-9	WEHI-539 was designed as a BCL-XLinhibitor with high affinity.It interacted the with the binding groove of BCL-XLwith a Kd value of 0.6nM.In MEF cells lacking MCL-1,WEHI-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing.	price>
R-C-2583	SMIP004 CAS:143360-00-3	SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells.SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors,and resulted in G1 arrest, inhibition of colony formation in soft agar,and cell death.	price>

...