Product apis-apoptosis

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Catalog	name	Description	price
R-C-2584	WR 1065 CAS:14653-77-1	WR 1065,a dephosphorylated metabolite of amifostine(Ethyol),can protect against the immediate and delayed effects of radiation exposure.	price>
R-C-2586	Nolatrexed (AG-337) CAS:152946-68-4	Nolatrexed dihydrochloride(AG 337)is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme,with a Ki of 11nM for human thymidylate synthase.Nolatrexed dihydrochloride(AG 337)induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.	price>
R-C-2587	A-1210477 CAS:1668553-26-1	A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45nM. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner.	price>
R-C-2590	mricasan (IDN-6556) CAS:254750-02-2	Emricasan(PF 03491390,IDN-6556)is an orally active and irreversible pan-caspase inhibitor.Emricasan inhibits Zika virus(ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.	price>
R-C-2592	AZ 10417808 CAS:331645-84-2	AZ 10417808 is a selective caspase-3 inhibitor with IC50 value of 14.9uM.AZ 10417808(AQZ-1)is a potent small molecule nonpeptidic inhibitor of caspase-3, which block cellular and biochemical features of apoptosis.	price>
R-C-2593	Muristerone A CAS:38778-30-2	Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax.	price>
R-C-2594	SJ 172550 CAS:431979-47-4	SJ 172550 is the first MDMX inhibitor with EC50 of 0.84uM;binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.	price>
R-C-2596	Plumbagin CAS:481-42-5	Plumbagin,exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma;has antifungal,antiviral,and antibacterial action.	price>
R-C-2598	Matrine CAS:519-02-8	Matrine,a novel autophagy inhibitor,possesses anti-inflammation, immunosuppression,anti-fibrotic and anticancer activities,it could inhibit cell proliferation and induce apoptosis of SGC-7901 cells in vitro by up-regulating Fas/FasL expression and activating caspase-3 enzyme.	price>
R-C-2599	Embelin CAS:550-24-3	Embelin(Embelic acid),a potent,nonpeptidic XIAP inhibitor(IC50=4.1μM), inhibits cell growth,induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP.Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.	price>

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