Product apis-Inhibitor-customization

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Catalog	name	Description	price
R-C-1431	Pagoclone CAS：133737-32-3	Pagoclone,an active(+)-enantiomer of the racemate RP 59037,is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and anxiety disorders.	price>
R-C-1432	Trovafloxacin CAS：147059-72-1	Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive,Gram-negative and anaerobic organisms.Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity.Trovafloxacin is also a potent,selective and orally active pannexin 1 channel(PANX1)inhibitor with an IC50 of 4 μM for PANX1 inward current.Trovafloxacin does not inhibit connexin 43 gap junction or PANX2.Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.	price>
R-C-1433	LDC000067 CAS：1073485-20-7	LDC000067 is a potent and selective CDK9 inhibitor.LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner.Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs,including important regulators of proliferation and apoptosis. Analysis of de novo RNA synthesis suggested a wide ranging positive role of CDK9.At the molecular and cellular level,LDC000067 reproduced effects characteristic of CDK9 inhibition such as enhanced pausing of RNA polymerase II on genes and, most importantly,induction of apoptosis in cancer cells.LDC000067 inhibits P-TEFb-dependent in vitro transcription.Induces apoptosis in vitro and in vivo in combination with BI 894999.	price>
R-C-1459	PYRACLONIL CAS：158353-15-2	Pyraclonil is a proporphyrinogen oxidase(PPO)inhibitor.Pyraclonil is a herbicide agent and is highly effective in controlling the susceptible(S)and multiple-herbicide-resistant(MHR)E.indica populations.	price>
R-C-1460	Mitoquinone CAS:444890-41-9	Mitoquinone is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage.	price>
R-C-1481	GSK2330672 CAS:1345982-69-5	Linerixibat(GSK2330672)is a highly potent,nonabsorbable and orally active apical sodium-dependent bile acid transporter(ASBT)inhibitor with an IC50 of 42 nM human ASBT.Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment.	price>
R-C-1498	AG-120(Ivosidenib) CAS:1448347-49-6	AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1),with potential antineoplastic activity.	price>
R-C-1512	AAL-993 cas:269390-77-4	AAL-993 is a potent,selective and cell-permeable inhibitor of VEGFR-1(IC₅₀=130 nM),VEGFR-2(IC₅₀=23 nM)and VEGFR-3(IC₅₀=18nM).At higher concentrations it inhibits PDGFR(640 nM),c-Kit(236 nM)and CSF-1R(380 nM).Inactive at other kinases such as EGFR,FGFR-1,CDK-1,Tie-2,c-Met,IGF-1R,c-Src and c-Abl.	price>
R-C-1515	YYA-021 CAS:144217-65-2	YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry,with high anti-HIV activity and low cytotoxicity.	price>
R-C-1518	BTZ043 CAS:1161233-85-7	BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase(DprE1),with MICs of of 2.3 nM and 9.2 nM for M.tuberculosis H37Rv and Mycobacterium smegmatis, respectively.	price>

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