Product apis-Inhibitor-customization

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Catalog	name	Description	price
R-C-1197	CPI-268456	CPI-268456 is a ligand of bromodomain-containing protein 4(BRD4).It binds to BRD4(IC5=<0.5 µM in a cell-free assay)and inhibits LPS-induced IL-6 secretion in THP-1 cells(IC50=<0.5 µM).	price>
R-C-1217	TPT-260 CAS NO. 769856-81-7	TPT-260(TPU260)is a thiophene thiourea derivative with molecule weight 260.00 in free base form;There is no formal name yet,we temporally call this molecule as TPT-260.	price>
R-C-1219	CTX0294885 CAS:1439934-41-4	CTX-0294885 is a novel broad-spectrum kinase inhibitor.CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro.	price>
R-C-1226	DBPR211 Cas:1429239-98-4	CB1-IN-1(also known as DBPR211)is a novel,potent,peripherally restricted antagonist of the CB1R(cannabinoid 1 receptor)with Ki values of 0.3 nM and 21 nM for CB1R(EC50 of 3 nM)and CB2R,respectively.CB1-IN-1 has shown significant weight-loss effects and can decrease hepatic steatosis as well as insulin resistance in a diet-induced obese mice model.Therefore,it has great potential to be used in this related metabolic syndrome such as obesity.It also has favorable PK profiles including an extremely low brain to plasma ratio suggesting a low probability to cross BBB.	price>
R-C-1261	YL-109 CAS ： 36341-25-0	YL-109 has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.YL-109 repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures.YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein(CHIP),which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway.YL-109 induced CHIP transcription because of the recruitment of the aryl hydrocarbon receptor(AhR)to upstream of CHIP gene in MDA-MB-231 cells.Consistently,the antitumor effects of YL-109 were depressed by CHIP or AhR knockdown in MDA-MB-231 cells.YL-109 inhibits cell growth and metastatic potential by inducing CHIP expression through AhR signaling and reduces cancer stem cell properties in MDA-MB-231 cells.	price>
R-C-1273	PCI-27483 CAS No. 871266-63-6	PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa)with potential antineoplastic and antithrombotic activities.FVII,a serine protease,becomes activated(FVII)aupon binding with TF forming the FVIIa/TF complex,which induces intracellular signaling pathways by activating protease activated receptor 2(PAR-2).Upon subcutaneous administration,factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex,which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways,thereby inhibiting tumor cell proliferation,angiogenesis,and metastasis of TF-overexpressing tumor cells.	price>
R-C-1288	Ibutamoren (MK-677) CAS：159634-47-6	Ibutamoren,also known as MK-677(L-163,191),is a drug which acts as a potent, orally active growth hormone secretagogue,mimicking the GH stimulating action of the endogenous hormone ghrelin.	price>
R-C-1301	TP-434 (Eravacycline) CAS：1207283-85-9	TP-434 is a novel,broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.	price>
R-C-1302	cambendazol CAS：26097-80-3	Cambendazol is an antihelmintic that,at a dose of 50 mg/kg/day in mice, eradicates S.ratti adult worms from intestine and S.stercoralis larva from muscle.It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2µM.	price>
R-C-1324	AZ7371 CAS：1494675-86-3	AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2-epimerase(DprE1;IC50=10nM),an enzyme involved in mycobacterial cell wall biogenesis.1 It inhibits wild-type M.smegmatis DprE1 and DprE1 harboring the drug-resistance mutation C394G(IC50=0.01 µM for both)but not the Y321H mutation (IC50=>10 µM).	price>

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