PCI-27483 CAS No. 871266-63-6

PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa)with potential antineoplastic and antithrombotic activities.FVII,a serine protease,becomes activated(FVII)aupon binding with TF forming the FVIIa/TF complex,which induces intracellular signaling pathways by activating protease activated receptor 2(PAR-2).Upon subcutaneous administration,factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex,which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways,thereby inhibiting tumor cell proliferation,angiogenesis,and metastasis of TF-overexpressing tumor cells.

msds---PCI-27483