Product apis-Inhibitor-customization

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Catalog	name	Description	price
R-C-994	YH249	YH249 is the first highly specific,direct p300/β-catenin antagonist.	price>
R-C-1003	tomeglovir cas:233254-24-5	Tomeglovir is a potent anti-CMV agent,inhibiting processing of viral DNA-concatemers,with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.	price>
R-C-1007	K145 (hydrochloride) cas:1449240-68-9（HCl）	K145 hydrochloride accumulates in U937 cells,suppresses the S1P level, and inhibits SphK2 by using human leukemia U937 cells in vitro studies.K145 hydrochloride exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells,and that these effects may be through the inhibition of down-stream ERK and Akt signaling pathways.K145 hydrochloride significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration,thus demonstrating its in vivo efficacy as a potential lead anticancer agent.The antitumor activity of K145 was also confirmed in a syngeneic mouse model by implanting murine breast cancer JC cells in BALB/c mice.	price>
R-C-1016	TH-237A CAS NO. 935467-97-3	TH-237A is a novel neuroprotective agent,which possess protective properties against β-amyloid(Aβ)-induced neurodegeneration associated with Alzheimer is disease.	price>
R-C-1027	Deferitrin C AS NO. 239101-33-8	Deferitrin is a novel, orally available iron chelator.Deferitrin may be useful as chelation monotherapy or as part of combination or doublet chelation therapy for the treatment of severe iron overload in patients with beta-thalassemia major if its favorable pharmacokinetic profile,efficacy,safety and tolerability are confirmed in more extensive clinical trials.A phase I/II clinical trial that began in September 2003 has reportedly completed recruitment.Deferitrin was safe,well-tolerated,and well-absorbed either with food and fasting in beta-thalassemia patients.Renal excretion of deferitrin uncomplexed with iron was similar to that seen in preclinical studies,which predict iron excretion to be via the fecal route.Further studies are ongoing to define the effect of deferitrin on iron balance.	price>
R-C-1073	(R)-FL-118 CAS:151636-76-9	(R)-FL-118 is a derivative of Camptothecin(C175150),which is antitumor alkaloid that binds to the DNA-topoisomerase I complex,inhibiting the reassociation of DNA after cleavage by topoisomerase I,trapping the enzyme in a covalent linkage with DNA.	price>
R-C-1082	Ro 48-8071 fumarate CAS:89197-69-1	Ro 48-8071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range;in cells it triggered the production of monooxidosqualene, dioxidosqualene,and epoxycholesterol.Administration of Ro 48-8071 to mice with BT-474 tumor xenografts prevented tumor growth,with no apparent toxicity.Ro 48-8071 degraded ERα while concomitantly inducing the anti-proliferative protein ERβ.	price>
R-C-1095	TPT-260 Dihydrochloride CAS:2076-91-7	TPT-260 Dihydrochloride(NSC55712)is a thiophene thiourea derivative with molecule weight 260.00 in free base form;There is no formal name yet,we temporally call this molecule as TPT-260.	price>
R-C-1101	FK-3311 CAS：116686-15-8	FK-3311(COX-2 Inhibitor V)is a selective,cell-permeable and orally available inhibitor of cyclooxygenase-2(COX-2)with antiinflammatory.FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.	price>
R-C-1104	Ixazomib (MLN2238 ) CAS: 1072833-77-2	Ixazomib(MLN2238)inhibits the chymotrypsin-like proteolytic(β5)site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively,also inhibits the caspase-like(β1)and trypsin-like(β2) proteolytic sites,with IC50 of 31 and 3500 nM.Ixazomib(MLN2238) induces autophagy.	price>

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