Product apis-neuronal-signaling

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Catalog	name	Description	price
R-C-2782	Sumatriptan CAS:103628-46-2	Sumatriptan succinate is a selective 5-HT1 receptor agonist with specificity towards 5-HT1D,5-HT1B and 5-HT1A.	price>
R-C-2783	Thioperamide CAS:106243-16-7	Thioperamide(MR-12842)is a potent,orally available,brain penetrant and selective H3 receptor antagonist with a Ki of 4.3nM for inhibition of [3H]histamine release.Thioperamide inhibits [3H]histamine synthesis with a Ki of 31nM.	price>
R-C-2784	Risperidone CAS:106266-06-2	Risperidone is a serotonin 5-HT2 receptor blocker,P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist,with Kis of 4.8,5.9nM for 5-HT2A and dopamine D2 receptor,respectively.	price>
R-C-2785	A 987306 CAS:1082954-71-9	A-987306 is a potent histamine H4 receptor antagonist that is selective for H3,H1 and H2 receptors.A-987306 blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo.	price>
R-C-2786	Mizolastine CAS:108612-45-9	Mizolastine is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever(seasonal allergic rhinitis),hives and other allergic reactions.	price>
R-C-2787	BP 554 maleate CAS:1221401-95-1	BP-554 maleate is a selective agonist of 5-HT1A receptor.BP-554 maleate is a selective 5-HT1A receptor agonist.BP-554 showed higher affinity for 5-HT1A receptor than for 5-HT1-non-A,5-HT2,α2-adrenergic,dopamine D2 and benzodiazepine receptors.	price>
R-C-2788	MFZ 10-7 CAS:1224431-15-5	High affinity negative allosteric modulator at the mGlu5 receptor(Ki=0.67nM).Potently inhibits mGlu5 glutamate-mediated calcium mobilization(IC50=1.22nM).Inhibits cocaine-taking and cocaine-seeking behavior in rats.	price>
R-C-2789	ATB-346 CAS:1226895-20-0	Otenaproxesul(ATB-346),an orally active non-steroidal anti-inflammatory drug(NSAID),inhibits cyclooxygenase-1 and 2(COX-1 and 2).Otenaproxesul possesses antiinflammatory and antinociceptive activities.	price>
R-C-2790	AZD3839 CAS:1227163-84-9	AZD3839 free base is a potent and selective orally active,brain-permeable BACE1 inhibitor(Ki=26nM).AZD3839 free base shows 14 and>1000-fold selectivity against BACE2 and cathepsin D,respectively.AZD3839 free base exhibits dose-and time-dependent lowering of plasma,brain,and cerebrospinal fluid Aβ levels in mouse,guinea pig,and non-human primate.	price>
R-C-2791	Iguratimod CAS:123663-49-0	Iguratimod is an antirheumatic agent,acts as an inhibitor of COX-2,with an IC50 of 20μM(7.7μg/mL),but shows no effect on COX-1.Iguratimod also inhibits macrophage migration inhibitory factor(MIF)with an IC50 of 6.81μM.	price>

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