Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3599	L748337 CAS No.244192-94-7	L748337/CAS No.244192-94-7 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.	price>
R-C-1900	BD1063 HCl CAS：206996-13-6	BD1063 2HCL(BD1063 dihydrochloride)is a potent and selective sigma-1 receptor (σ1R)antagonist with Ki of 4.43nM.	price>
R-R-3600	Atipamezole hydrochloride CAS No.104075-48-1	Atipamezole (MPV-1248) hydrochloride/CAS No.104075-48-1 is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.	price>
R-R-3601	Pronethalol CAS No.54-80-8	Pronethalol ((±)-Pronethalo)/CAS No.54-80-8 is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs).	price>
R-R-3602	Metoprolol succinate CAS No.98418-47-4	Metoprolol succinate/CAS No.98418-47-4 is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.	price>
R-R-3603	Guanabenz hydrochloride CAS No.23113-43-1	Guanabenz hydrochloride/CAS No.23113-43-1 is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure.	price>
R-R-3604	BI-167107 CAS No.1202235-68-4	BI-167107/CAS No.1202235-68-4 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM.	price>
R-R-3605	Reboxetine mesylate CAS No.98769-84-7	Reboxetine mesylate (FCE20124 mesylate)/CAS No.98769-84-7 is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM.	price>
R-R-3606	Idazoxan hydrochloride CAS No.79944-56-2	Idazoxan hydrochloride (RX 781094 hydrochloride)/CAS No.79944-56-2 is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs).	price>
R-R-3607	Vibegron CAS No.1190389-15-1	Vibegron (MK-4618)/CAS No.1190389-15-1 is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder.	price>

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