Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3591	Dexmedetomidine hydrochloride CAS No.145108-58-3	Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride)/CAS No.145108-58-3 is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.	price>
R-R-3592	Dobutamine hydrochloride CAS No.49745-95-1	Dobutamine hydrochloride/CAS No.49745-95-1 is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.	price>
R-R-3593	Atomoxetine hydrochloride CAS No.82248-59-7	Atomoxetine (Tomoxetine) hydrochloride/CAS No.82248-59-7 is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.	price>
R-R-3594	Terazosin hydrochloride dihydrate CAS No.70024-40-7	Terazosin hydrochloride dihydrate/CAS No.70024-40-7 is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.	price>
R-C-2255	Amarogentin CAS：21018-84-8	Amarogentin(AG),a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots,exhibits anti-oxidative,anti-tumour,and anti-diabetic activities.Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α.Amarogentin induces apoptosis in human gastric cancer cells(SNU-16)through G2/M cell cycle arrest and PI3K/Akt signalling pathway.	price>
R-R-3595	Clonidine CAS No.4205-90-7	Clonidine/CAS No.4205-90-7 is an alpha 2-adrenergic agonist.	price>
R-R-3596	Tamsulosin CAS No.106133-20-4	Tamsulosin ((R)-(-)-YM12617 free base)/CAS No.106133-20-4 is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models.	price>
R-R-3597	SR59230A hydrochloride CAS No.1135278-41-9	SR59230A hydrochloride/CAS No.1135278-41-9 is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.	price>
R-R-3598	Guanfacine hydrochloride CAS No.29110-48-3	Guanfacine hydrochloride/CAS No.29110-48-3 is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette syndrome and attention deficit hyperactivity disorder (ADHD).	price>
R-R-3599	L748337 CAS No.244192-94-7	L748337/CAS No.244192-94-7 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.	price>

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