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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4126 CB2R/FAAH modulator-3 CAS No.2876918-67-9 CB2R/FAAH modulator-3 (compound 27)/CAS No.2876918-67-9 is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection. price>
R-R-4127 PGN36 CAS No.1564253-75-3 PGN36 (Compound 18)/CAS No.1564253-75-3 is a selective cannabinoid CB2 receptor (CB2R) antagonist with a Ki of 0.09 µM. price>
R-R-4128 AM6545 CAS No.1245626-05-4 AM6545/CAS No.1245626-05-4 is a peripherally active, cannabinoid receptor antagonist with limited brain penetration. AM6545 binds to CB1 and CB2 receptors with Kis of 1.7 nM and 523 nM, respectively. AM6545 is a neutral antagonist. AM6545 can be used for the research of obesity and its complications. price>
R-R-4129 2-Palmitoylglycerol CAS No.23470-00-0 2-Palmitoylglycerol (2-Palm-Gl)/CAS No.23470-00-0, an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119. price>
R-R-4130 CB-25 CAS No.869376-63-6 CB-25/CAS No.869376-63-6 is a ligand of CB1 cannabinoid receptors, acting as a partial agonist. CB-25 enhances Forskolin (HY-15371)-induced cAMP formation in cancer cells but not hCB1-CHO cells. price>
R-R-4131 β-Caryophyllene-d2 CAS No.2006272-96-2 β-Caryophyllene-d2/CAS No.2006272-96-2 is deuterium labeled β-Caryophyllene. β-Caryophyllene is a CB2 receptor agonist. price>
R-R-4132 CB1/2 agonist 1 CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC50s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis. price>
R-R-4133 2-Linoleoyl glycerol CAS No.3443-82-1 3-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol)/CAS No.3443-82-1 is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG). price>
R-R-4134 PSNCBAM-1 CAS No.877202-74-9 PSNCBAM-1/CAS No.877202-74-9 is a selective CB1 receptor allosteric antagonist with an EC50 of 0.1 μM. PSNCBAM-1 can be used in the researches of obesity. price>
R-R-4135 RTICBM-189 CAS No.551909-15-0 RTICBM-189/CAS No.551909-15-0 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats. price>