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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4059 PD176252 CAS No.204067-01-6 PD176252/CAS No.204067-01-6 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells. price>
R-R-4060 MK-5046 CAS No.1022152-70-0 MK-5046/CAS No.1022152-70-0 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity. price>
R-R-4061 RC-3095 TFA CAS No.1217463-61-0 RC-3095 TFA/CAS No.1217463-61-0 is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice. price>
R-R-4062 ML-18 CAS No.1422269-30-4 ML-18/CAS No.1422269-30-4 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC50 of 4.8 μM. price>
R-R-4063 BIM 23042 TFA BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release. price>
R-R-4064 PD 168368 CAS No.204066-82-0 PD 168368/CAS No.204066-82-0 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the Ki of 15–45 nM. PD 168368 is neuromedin B receptor (NMBR; IC50=96 nM) / gastrin-releasing peptide receptor (GRPR IC50=3500 nM) antagonist. PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50s of 0.57, 0.24, and 2.7 nM, respectively. price>
R-R-4065 Kuwanon G CAS No.75629-19-5 Kuwanon G/CAS No.75629-19-5 is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity. price>
R-R-4066 Kuwanon H CAS No.76472-87-2 Kuwanon H/CAS No.76472-87-2 is a flavonoid isolated from Morus alba, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells. price>
R-R-4067 Bradykinin CAS No.58-82-2 Bradykinin/CAS No.58-82-2 is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions. price>
R-R-4068 Icatibant CAS No.130308-48-4 Icatibant (HOE-140)/CAS No.130308-48-4 is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. price>