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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4053 MM 07 CAS No.1876450-21-3 MM 07/CAS No.1876450-21-3 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart. price>
R-R-4054 Apelin-17(human, bovine) CAS No.217082-57-0 Apelin-17(human, bovine)/CAS No.217082-57-0 is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ. price>
R-R-4055 MM 54 CAS No.1313027-43-8 MM 54 (compound 5)/CAS No.1313027-43-8 is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation. price>
R-R-4056 ML233 CAS No.2080311-92-6 ML233/CAS No.2080311-92-6 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM). price>
R-R-4057 Apelin-36(rat, mouse) CAS No.230299-95-3 Apelin-36(rat, mouse)/CAS No.230299-95-3 is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. price>
R-R-4058 Bombesin CAS No.31362-50-2 Bombesin/CAS No.31362-50-2, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors. price>
R-R-4059 PD176252 CAS No.204067-01-6 PD176252/CAS No.204067-01-6 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells. price>
R-R-4060 MK-5046 CAS No.1022152-70-0 MK-5046/CAS No.1022152-70-0 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity. price>
R-R-4061 RC-3095 TFA CAS No.1217463-61-0 RC-3095 TFA/CAS No.1217463-61-0 is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice. price>
R-R-4062 ML-18 CAS No.1422269-30-4 ML-18/CAS No.1422269-30-4 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC50 of 4.8 μM. price>