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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4051 BMS-986224 CAS No.2055200-88-7 BMS-986224/CAS No.2055200-88-7 is a potent, selective and orally active APJ receptor agonist (Kd = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr1) apelin-13. BMS-986224 has the potential for the research of heart failure. price>
R-R-4052 CMF019 CAS No.1586787-08-7 CMF019/CAS No.1586787-08-7 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. price>
R-R-4053 MM 07 CAS No.1876450-21-3 MM 07/CAS No.1876450-21-3 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart. price>
R-R-4054 Apelin-17(human, bovine) CAS No.217082-57-0 Apelin-17(human, bovine)/CAS No.217082-57-0 is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ. price>
R-R-4055 MM 54 CAS No.1313027-43-8 MM 54 (compound 5)/CAS No.1313027-43-8 is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation. price>
R-R-4056 ML233 CAS No.2080311-92-6 ML233/CAS No.2080311-92-6 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM). price>
R-R-4057 Apelin-36(rat, mouse) CAS No.230299-95-3 Apelin-36(rat, mouse)/CAS No.230299-95-3 is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. price>
R-R-4058 Bombesin CAS No.31362-50-2 Bombesin/CAS No.31362-50-2, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors. price>
R-R-4059 PD176252 CAS No.204067-01-6 PD176252/CAS No.204067-01-6 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells. price>
R-R-4060 MK-5046 CAS No.1022152-70-0 MK-5046/CAS No.1022152-70-0 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity. price>