Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4654	Anticancer agent 73 CAS No.124811-87-6	Anticancer agent 73 (compound CIB-3b)/CAS No.124811-87-6 is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo.	price>
R-R-4655	L82-G17 CAS No.92285-87-5	L82-G17/CAS No.92285-87-5 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity.	price>
R-R-4656	PCNA-I1 CAS No.444930-42-1	PCNA-I1/CAS No.444930-42-1 is a potent PCNA (proliferating cell nuclear antigen) inhibitor. PCNA-I1 directly binds PCNA trimers with a Kd of 0.41 μM and exhibits antitumor activity both in vitro and in vivo.	price>
R-R-4657	CP681301 CAS No.865317-32-4	CP681301/CAS No.865317-32-4 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila.	price>
R-R-4658	b-Amanitin CAS No.21150-22-1	β-Amanitin/CAS No.21150-22-1 is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs).	price>
R-R-4659	Lomibuvir CAS No.1026785-55-6	Lomibuvir (VX-222)/CAS No.1026785-55-6, a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.	price>
R-R-4660	Clevudine CAS No.163252-36-6	Clevudine (L-FMAU)/CAS No.163252-36-6, a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice.	price>
R-R-4661	RG7800 tetrahydrochloride	RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.	price>
R-R-4662	Rifalazil CAS No.129791-92-0	Rifalazil (KRM-1648; ABI-1648)/CAS No.129791-92-0, a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB).	price>
R-R-4663	T2AA CAS No.1380782-27-3	T2AA/CAS No.1380782-27-3 is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase.	price>

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