Product apis-cytoskeletal-signaling

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Catalog	name	Description	price
R-C-2174	Pracinostat (SB939) CAS:929016-96-6	Pracinostat(SB939)is an orally bioavailable,small-molecule histone deacetylase(HDAC)inhibitor with potential antineoplastic activity.Pracinostat inhibits HDACs,which may result in the accumulation of highly acetylated histones,followed by the induction of chromatin remodeling;the selective transcription of tumor suppressor genes;the tumor suppressor protein-mediated inhibition of tumor cell division;finally,the induction of tumor cell apoptosis.	price>
R-C-2175	Droxinostat CAS: 99873-43-5	Droxinostat(NS41080)is a selective inhibitor of HDAC3,HDAC6,and HDAC8 with IC50 of 16.9,2.47 and 1.46μM,respectively;>8-fold selective against HDAC3 and no inhibition to HDAC1,2,4,5,7,9,and 10.	price>
R-C-2176	Abexinostat (PCI-24781) CAS: 783355-60-2	Abexinostat(PCI-24781,CRA-024781)is novel,broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase(HDAC)with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC,resulting in an accumulation of highly acetylated histones,followed by the induction of chromatin remodeling;the selective transcription of tumor suppressor genes;and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.	price>
R-C-2195	Nocodazole (R17934) CAS: 31430-18-9	Nocodazole(Oncodazole)is a rapidly-reversible inhibitor of microtubule.Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics,which prevents mitosis and induces apoptosis in tumor cells.Nocodazole inhibits Bcr-Abl,and activates CRISPR/Cas9.	price>
R-C-2450	M344 CAS：251456-60-7	M344(D 237)is an inhibitor of histone deacetylase(IC50=100nM)and an inducer of terminal cell fifferentiation.	price>
R-C-2493	HSP-990 CAS:934343-74-5	NVP-HSP990 is a potent and selective Hsp90 inhibitor,with IC50 values of 0.6,0.8,and 8.5nM for Hsp90α,Hsp90β,and Grp94,respectively.	price>
R-C-2556	Dynasore CAS:304448-55-3	Dynasore is a cell-permeable,reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2,with IC50 of 15μM in a cell-free assay,also inhibits the mitochondrial dynamin Drp1,with no effect against other small GTPase.Dynasore suppresses mTORC1 activity and induces autophagy.	price>
R-C-2557	KY02111 CAS:1118807-13-8	KY02111 is a potent and selective inhibitor of Wnt.KY02111 promotes differentiation of hPSCs by inhibiting WNT signaling that is distinct.KY 02111 may by targeting the downstream from GSK3βand APC in β-catenin destruction complex.	price>
R-C-2559	CK636 CAS:442632-72-6	CK-636 is a cell permeable inhibitor of Arp2/3 complex,that could inhibit actin polymerization,with IC50 values of 4μM,24μM and 32μM for human,fission yeast and bovine,respectively.	price>
R-C-2615	Midostaurin (PKC412) CAS:120685-11-2	Midostaurin(PKC412;CGP 41251)is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ,Syk,Flk-1,Akt,PKA,c-Kit,c-Fgr,c-Src,FLT3,PDFRβ and VEGFR1/2 with IC50s ranging from 22-500nM.	price>

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