Product apis-cytoskeletal-signaling

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Catalog	name	Description	price
R-C-1306	GFT-505 CAS：923978-27-2	Elafibranor,also known as GFT-505,is a dual PPARα/δagonist.Elafibranoris currently being studied for the treatment of cardiometabolic diseases including diabetes,insulin resistance,dyslipidemia,and non-alcoholic fatty liver disease (NAFLD).	price>
R-C-1345	Eliprodil (SL-820715） CAS：119431-25-3	Eliprodil,aslo known as SL-82,0715;is a NMDA antagonist.NMDA receptors are a key component in mediating glutamate-induced excitotoxicity,and it is believed that NMDA antagonists would be neuroprotective after a stroke or other traumatic brain injury.Eliprodil protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage.Eliprodil stimulates CNS myelination,may be a new prospect for multiple sclerosis.	price>
R-C-1386	PF-3758309 CAS: 898044-15-0	PF-3758309,also known as PF-03758309,is a PAK4 inhibitor,is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4(PAK4)with potential antineoplastic activity.PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth.PAK4,a serine/threonine kinase belonging to the p21-activated kinase(PAK)family,is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility,proliferation,and survival.	price>
R-C-1388	CWHM12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>
R-C-1395	ARQ621 CAS：1095253-39-6	ARQ-621 is an allosteric,potent and selective inhibitor of Eg5,a microtubule-based ATPase motor protein involved in cell division.Over-expression of Eg5 causes genomic instability and tumor formation in mice;therefore,Eg5 is a potential anti-cancer target.Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies.	price>
R-C-1525	CWHM-12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>
R-C-1544	MMAF CAS ： 745017-94-1	MMAF(Monomethylauristatin F)is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization.MMAF(Monomethylauristatin F)is applied as a cytotoxic component of antibody-drug conjugates(ADCs)such as vorsetuzumab mafodotin,ABT-414 and SGN-CD19A.	price>
R-C-1545	DM1-Sme CAS：138148-68-2	DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group.	price>
R-C-1563	Apoptozole CAS：1054543-47-3	Apoptozole(Apoptosis Activator VII)is an inhibitor of heat shock protein 70(HSP70)and Hsc70 with dissociation constants Kd of 0.14μM and 0.21μM, respectively.It induces caspase-dependent apoptosis.	price>
R-C-1646	Lys05 CAS:1391426-22-4	Lys05 is a potent lysosomal autophagy inhibitor.Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ.	price>

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