Product apis-cytoskeletal-signaling

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Catalog	name	Description	price
R-C-1170	cevipabulin CAS：849550-05-6	Cevipabulin(TTI-237),an antimicrotubule agent,is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity.With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site,and promotes the polymerization of tubulin into microtubules.	price>
R-C-1174	Luminespib(NVP-AUY922) CAS：747412-49-3	Luminespib(AUY-922,NVP-AUY922,VER-52296)is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays,weaker potency against the HSP90 family members GRP94 and TRAP-1,exhibits the tightest binding of any small-molecule HSP90 ligand.Luminespib(AUY-922,NVP-AUY922)effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition,autophagy and apoptosis.	price>
R-C-1200	GSK923295 Cytoskeletal Signaling	GSK-923295 is a special,allosteric inhibitor of centromere-associated protein-E (CENP-E)kinesin motor ATPase activity,with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine,respectively.	price>
R-C-1202	MMAE CAS:474645-27-7	Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization.1 Monomethyl Auristatin E(MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity.It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.2,3 MMAE is typically coupled to the antibody via a protease-cleavable linker,allowing separation of the drug from the antibody following intracellular localization.	price>
R-C-1224	ELR510444 CAS：1233948-35-0	ELR510444 is a novel microtubule disruptor;inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM;not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.	price>
R-C-1246	Arry-520 (Filanesib) CAS:885060-09-3	Filanesib,also known as ARRY-520,is a synthetic,small molecule targeting the kinesin spindle protein(KSP)with potential antineoplastic activity.KSP inhibitor ARRY-520 specifically inhibits KSP(kinesin-5 or Eg5),resulting in activation of the spindle assembly checkpoint,induction of cell cycle arrest during the mitotic phase,and consequently cell death in tumor cells that are actively dividing.KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.	price>
R-C-1249	BIIB021(CNF2024) CAS：848695-25-0	BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.	price>
R-C-1252	Mdivi-1 CAS：338967-87-6	Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division dynamin-related GTPase(DRP1)and mitochondrial division dynamin I(Dnm1).Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. Mdivi-1 represents a class of therapeutics for stroke,myocardial infarction,and neurodegenerative diseases.	price>
R-C-1279	Vesnarinone CAS:81840-15-5	Vesnarinone is a cardiotonic agent,mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest,dose-dependent,positive inotropic activity,but minimal negative chronotropic activity.Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.	price>
R-C-1291	Fimepinostat (CUDC-907) CAS：1339928-25-4	Fimepinostat(CUDC-907)potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10,respectively.	price>

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