Product apis-cytoskeletal-signaling

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Catalog	name	Description	price
R-C-1733	Emixustat Hydrochlorde cas:1141934-97-5	Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232±3nM.	price>
R-C-1836	ULM-1(MDK7526HCL) CAS:228544-65-8	VULM-1457 is an Acyl-CoA cholesterol acyltransferase(ACAT)inhibitor.	price>
R-C-1839	VCMMAE CAS:646502-53-6	VcMMAE(mc-vc-PAB-MMAE),a MMAE derivative with valine-citrulline(Vc)linker,is an antibody-drug conjugate(ADC)with potent antitumor activity.MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.	price>
R-C-1869	3-TYP CAS:120241-79-4	3-TYP is a selective SIRT3 inhibitor,with an IC50 of 16 nM,more potent over SIRT1(IC50=88nM),SIRT2(IC50=92nM).	price>
R-C-1902	Monastrol CAS：329689-23-8	Monastrol((±)-Monastrol)is a cell-permeable small molecule inhibitor of kinesin-5(KIF11)which is essential for maintaining separation of the half-spindles.	price>
R-C-1922	Cabazitaxel（XRP6258） CAS:183133-96-2	Cabazitaxel(RPR-116258A,XRP6258,TXD 258,Taxoid XRP6258)is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth.Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly,processes that are essential for cells to divide.Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.	price>
R-C-1948	CCF-642 CAS:346640-08-2	CCF642 is a potent protein disulfide isomerases(PDI)inhibitor with an IC50 of 2.9μM.CCF642 causes acute endoplasmic reticulum(ER)stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release.CCF642 has broad anti-multiple myeloma activity.	price>
R-C-2171	MC1568 CAS:852475-26-4	MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase,resulting in the death of breast cancer cells by apoptosis.	price>
R-C-2172	Givinostat (ITF2357) CAS: 732302-99-7	Givinostat(ITF2357)is a potent HDAC inhibitor for maize HD2,HD1B and HD1A with IC50 of 10 nM,7.5nM and 16nM in cell-free assays.	price>
R-C-2174	Pracinostat (SB939) CAS:929016-96-6	Pracinostat(SB939)is an orally bioavailable,small-molecule histone deacetylase(HDAC)inhibitor with potential antineoplastic activity.Pracinostat inhibits HDACs,which may result in the accumulation of highly acetylated histones,followed by the induction of chromatin remodeling;the selective transcription of tumor suppressor genes;the tumor suppressor protein-mediated inhibition of tumor cell division;finally,the induction of tumor cell apoptosis.	price>

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