Product apis-Inhibitor-customization

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Catalog	name	Description	price
R-C-2030	AX20017 CAS:329221-38-7	AX20017 is a small-molecule protein kinase G(PknG)inhibitor with an IC50 of 0.39μM.	price>
R-C-2035	MB-07811 ( VK-2809) CAS：852948-13-1	MB-07811(VK-2809)is an orally active HepDirect prodrug of MB07344,a liver-targeted thyroid hormone receptor-β agonist.MB-07811 has cholesterol and triglycerides lowering activity.	price>
R-C-2046	NS-3-008（HCl） CAS：1172854-54-4	NS-3-008 is an orally active transcriptional inhibitor of G0/G1 switch 2(G0s2). NS-3-008 can be used for chronic kidney disease.NS-3-008 inhibited the transcription of G0s2 with a half-maximal inhibitory concentration(IC50)of 2.25 μM.Moreover,treatment of wild-type 5/6Nx mice with NS-3-008 resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys.	price>
R-C-2063	Bromazine CAS：1808-12-4	Bromazine(trade names Ambodryl,Ambrodil and others),also known as bromodiphenhydramine,is an antihistamine and anticholinergic.It is a brominated form of diphenhydramine.	price>
R-C-2092	Resatorvid (TAK-242) CAS：243984-11-4	Resatorvid(TAK-242,CLI-095)is a small-molecule-specific inhibitor of Toll-like receptor(TLR)4 signaling,blocking LPS-induced production of NO,TNF-α and IL-6 in macrophages with IC50 of 1.8nM,1.9nM and 1.3nM,respectively.Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.	price>
R-C-2100	CT-1812 CAS：1802632-22-9	CT-1812 is a first-in-class,orally available sigma-2/PGRMC1 antagonist(alpha beta oligomer receptor antagonist),is being developed by Cognition.sCT-1812 is a novel therapeutic candidate for Alzheimer is disease.	price>
R-C-2102	Ingliforib CAS：186392-65-4	Ingliforib is a glycogen phosphorylase inhibitor,with IC50s of 52,352 and 150nM for liver,muscle and brain glycogen phosphorylase,and has cardioprotective activity.	price>
R-C-2107	PZ-2891 CAS：2170608-82-7	PZ-2891 is an orally bioavailable,brain penetrant pantothenate kinase (PANK)modulator.PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations.PZ-2891 inhibits human pantothenate kinases PANK1β,PANK2,and PANK3 with IC50s of 40.2 nM,0.7nM and 1.3nM,respectively.	price>
R-C-2109	AWZ1066S CAS：2239272-16-1	AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis,with an EC50 of 2.5nM in cell assay.	price>
R-C-2111	Spastazoline CAS：2351882-11-4	Spastazoline is a potent,cell-permeable and selective spastin(a microtubule-severing AAA(ATPases associated with diverse cellular activities) protein)inhibitor with IC50 of 99nM for Human spastin.Spastazoline does not inhibit ATPase activity of a recombinant human VPS4(another AAA protein required for intercellular bridge disassembly).	price>

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