Product apis-Inhibitor-customization

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Catalog	name	Description	price
R-C-2112	KL1333 CAS：1800405-30-4	KL1333,a derivative of β-lapachone,is an orally available NAD+modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1(NQO1)as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.	price>
R-C-2113	VUN34002（Vanin-1-IN-1 ） CAS：2173134-00-2	Vanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated,giycosyiphosphatidyS inositol(GPi)anchored protein and plays an important role in metabolism and inflammation.	price>
R-C-2114	Danicopan CAS： 1903768-17-1	Danicopan(ACH-4471,ACH-0144471,ACH-CFDIS,ALXN 2040)is a potent,selective and orally active inhibitor of factor D with Kd of 0.54nM for human Factor D. Danicopan inhibits alternative pathway of complement(APC)activity,and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria(PNH)and atypical hemolytic uremic syndrome(aHUS).	price>
R-C-2118	GS-4361 CAS：2291164-02-6	GS-4361 is a potent and selective IDO1 inhibitor with an EC50 of 17nM,GS-4361 was first reported in patent WO2019040102A.	price>
R-C-2119	NTN21277（Gefitinib-based PROTAC 3） CAS：2230821-27-7	NTN21277（Gefitinib-based PROTAC 3 )is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7nM and 22.3nM for HCC827 cell(Exon 19 del)and H3255 cell(L858R).	price>
R-C-2126	LY900009 CAS：209984-68-9	LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.LY900009 inhibited plasma levels of amyloid-β peptide in a dose-dependent manner with 80-90% inhibition observed in the 30-to 60-mg cohorts.	price>
R-C-2217	AUNP-12 CAS:1353563-85-5	AUNP-12(NP-12)is a peptide antagonist of the PD-1 signaling pathway,displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions.	price>
R-C-2218	BMS-1166 CAS:1818314-88-3	BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor.BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1,with an IC50 of 1.4 nM.BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.	price>
R-C-2220	Durvalumab (anti-PD-L1) CAS:1428935-60-7	Durvalumab(MEDI 4736)is an humanized anti-PD-L1 monoclonal antibody.Durvalumab (MEDI4736)completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04nM,respectively.	price>
R-C-2228	Lupenone CAS:1617-70-5	Lupenone,isolated from Rhizoma Musae,belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus,anti-diabetes,anti-cancer,improving Chagas disease without major toxicity.	price>

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