Product apis-ubiquitin

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Catalog	name	Description	price
R-C-2291	CC-885 CAS:1010100-07-8	CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1.was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1).GSPT1(also named eRF3a)is a translation termination factor that binds eukaryotic translation termination factor 1(eFR1)to mediate stop codon recognition and nascent protein release from the ribosome.	price>
R-C-2292	Mezigdomide (CC-92480) CAS:2259648-80-9	CC-92480,a cereblon E3 ubiquitin ligase modulating drug(CELMoD),acts as a molecular glue.CC-92480 shows high affinity to cereblon,resulting in potent antimyeloma activity.	price>
R-C-2293	Thalidomide-O-COOH (Cereblon ligand 3) CAS:1061605-21-7	Thalidomide-O-COOH(Cereblon ligand 3,E3 ligase Ligand 3),a Thalidomide-based Cereblon(CRBN)ligand,is used in the recruitment of CRBN protein. Thalidomide-O-COOH(Cereblon ligand 3)can be connected to the ligand for protein by a linker to form PROTACs(Proteolysis Targeting Chimera).	price>
R-C-2294	NAcM-OPT CAS:2089293-61-6	NAcM-OPT is an orally bioavailable cullin neddylation 1(DCN1)inhibitor,which potently inhibits the DCN1-UBE2M interaction.	price>
R-C-2295	NSC697923 CAS:343351-67-7	NSC697923 is a potent UBE2N(ubiquitin-conjugating enzyme E2 N,Ubc13) inhibitor. NSC697923 induces neuroblastoma(NB)cell death via promoting nuclear importation of p53 in p53 wild-type NB cells.NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway.NSC697923 inhibits DNA damage and NF-κB signaling.Antitumor activity.	price>
R-C-2300	Loureirin B CAS:119425-90-0	Loureirin B(LB,LrB),a flavonoid extracted from Dracaena cochinchinensis,is an inhibitor of PAI-1 with IC50 of 26.10μM.Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts.Loureirin B promotes insulin secretion mainly through increasing Pdx-1,MafA,intracellular ATP level,inhibiting the KATP current,influx of Ca2+ to the intracellular.	price>
R-C-2597	HLI 373 CAS:502137-98-6	HLI 373 is an inhibitor of Hdm2 ubiquitin ligase(E3)which blocks Hdm2-mediated ubiquitylation,proteasomal degradation of p53 and activates p53-dependent transcription.	price>
R-C-3101	TAK-981 CAS:1858276-04-6	TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.	price>
R-C-3102	N106 CAS:862974-25-2	N106,activator of SUMO-activating enzyme,E1 ligase.Increases SERCA2a SUMOylation and activity,and enhances contractility in rat cardiomyocytes in vitro.	price>
R-C-3103	COH000 CAS:1534358-79-6	COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro.	price>

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