Product apis-ubiquitin

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Catalog	name	Description	price
R-C-1838	VH298 CAS:2097381-85-4	VH298 is a potent VHL(Von Hippel-Lindau,the E3 ligase)inhibitor that stabilizes HIF-α.VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry(ITC)and 80 nM in a competitive fluorescence polarization assay.VH-298 can be used in PROTAC technology.	price>
R-C-2005	VL285 CAS:1448188-57-5	VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins. Cotreatment with excess VL285,the core VHL ligand from which HaloPROTAC3 is derived,is able to significantly reduce HaloPROTAC3 mediated activity to 50% degradation.	price>
R-C-2029	DKM2-93 CAS: 65836-72-8	DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430μM.	price>
R-C-2075	SJB2-043 CAS：63388-44-3	SJB2-043 is one of analogs/derivatives of C527,which is a novel and potent USP1 (ubiquitin-specific protease 1)inhibitor.	price>
R-C-2287	BC-1215 CAS:1507370-20-8	BC-1215 is an inhibitor of F-box protein 3(FBXO3,a ubiquitin E3 ligase component,IC50=0.9μg/mL for IL-1β release).BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination.BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215,interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC.	price>
R-C-2289	Apcin CAS:300815-04-7	Apcin(APC inhibitor)is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome(APC/C)that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.	price>
R-C-2208	2-D08 CAS:144707-18-6	2-D08 is a cell permeable,mechanistically unique inhibitor of protein sumoylation.It is also inhibits Axl,IRAK4,ROS1,MLK4,GSK3β,RET,KDR and PI3Kα with IC50 values of 0.49,3.9,5.3,9.8,11,11,17 and 35nM respectively in biochemical assays.	price>
R-C-2282	Pomalidomide (CC-4047) CAS:19171-19-8	Pomalidomide,the third-generation immunomodulatory agent,acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.	price>
R-C-2283	CC-90009 CAS:1860875-51-9	CC-90009 is a cereblon modulator.CC-90009 specifically binds to CRBN,thereby affecting the activity of the ubiquitin E3 ligase complex.This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors,including Ikaros(IKZF1)and Aiolos (IKZF3),which are transcriptional repressors in T-cells.This reduces the levels of these transcription factors,and modulates the activity of the immune system, which may include the activation of T-lymphocytes.	price>
R-C-2284	SZL P1-41 CAS: 222716-34-9	SZL P1-41(compound #25)is a specific inhibitor of S-phase kinase-associated protein 2(Skp2)that indeed binds to Skp2,prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity,which consequently suppresses survival of cancer cells and cancer stem cells.SZL P1-41 causes higher apoptosis rates in cancer cells.	price>

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