Catalog name Description price
R-C-604 PR-619 cas:2645-32-1 PR-619 is a cell-permeable,reversible,and broad-spectrum inhibitor of the deubiquitinylating enzymes(DUBs). price>
R-C-988 ML323 cas:1572414-83-5 ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay.The measured inhibition constants of ML-323 for the free enzyme(Ki)is 68 nM. price>
R-C-1139 Sibofimloc(VRT-1353385)CAS:1616113-45-1 Sibofimloc,also known as VRT-1353385 and Antibiotic-202,is an Escherichia coli fimbrial(FimH)adhesin inhibitor. price>
R-C-1247 DBeQ CAS:177355-84-9 DBeQ,also known as JRF 12,is a selective,reversible,and ATP-competitive inhibitor of the ATPase p97 for treatment of cancer.DBeQ impairs both ubiquitin-dependent and autophagic protein clearance pathways.DBeQ was shown to inhibit the ATPase activity of Vps4 with an IC50 of about 11.5 μM.To a less degree,it also inhibits hyphal growth.DBeQ blocks multiple processes that have been shown by RNAi to depend on p97,including degradation of ubiquitin fusion degradation and endoplasmic reticulum-associated degradation pathway reporters,as well as autophagosome maturation. price>
R-C-1264 NSC 687852 (b-AP15) CAS:1009817-63-3 b-AP15 is a novel inhibitor of proteasome deubiquitination.b-AP15 displays antitumor activity in several preclinical,solid tumor models.b-AP15 triggers time-and dose-dependent apoptosis of the human multiple myeloma(MM)cell lines RPMI8226 and U266,as determined by phosphatidylserine exposure.b-AP15 may have potential for treatment of multiple myeloma patients. price>
R-C-1362 prt4165 CAS No. 31083-55-3 PRT4165 is a small molecule inhibitor of polycomb repressive complex 1,which inhibits ubiquitin signaling at DNA double-strand breaks.PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro.The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks(DSBs),the retention of several DNA damage response proteins in foci that form around DSBs,and the repair of the DSBs. price>
R-C-1389 NMS-873 CAS:1418013-75-8 NMS-873 is a potent, allosteric and specific VCP inhibitor(also known as p97 inhibitor)with IC50 of 30 nM.NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death.The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target. price>
R-C-1640 Avadomide (CC-122) CAS:1015474-32-4 Avadomide(CC-122),a new chemical entity termed pleiotropic pathway modifier,is a novel agent for Diffuse large B-cell lymphoma(DLBCL)with antitumor and immunomodulatory activity.Its molecular target is the protein cereblon(CRBN),a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. price>
R-C-1780 P22077 CAS:1247819-59-5 P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease(IC??= 8.6μM)and the closely related deubiquitinase(DUB)USP47. price>
R-C-1804 Pevonedistat (MLN4924) CAS:905579-51-3 NAE inhibitor MLN4924 binds to and inhibits NAE,which may result in the inhibition of tumor cell proliferation and survival. price>