Product peptide-substrate-peptide

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Catalog	name	Description	price
R-M-500	Ac-Arg-Gly-Lys(Ac)-AMC trifluoroacetate salt	Ac-RGK(Ac)-AMC(CAS ：660846-97-9),fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin.	price>
R-M-501	Ac-Arg-Leu-Arg-AMC trifluoroacetate salt	Ac-RLR-AMC(CAS :929903-87-7),fluorogenic substrate for assaying the trypsin-like activity of purified proteasomes (Km = 78 μM).	price>
R-M-502	Ac-Arg-Ser-Leu-Lys-AMC trifluoroacetate salt	Ac-RSLK-AMC(CAS : 259176-76-6),a fluorogenic substrate for Site-1 protease (S1P), a mammalian subtilisin-related serine protease that cleaves sterol regulatory element-binding proteins (SREBPs).The peptide sequence RSLK corresponds to the internal propeptide cleavage site that generates active S1P.	price>
R-M-506	Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-L-lactoyl-Ser-Lys(DABCYL)-NH₂ ammonium salt	Internally quenched fluorogenic (FRET) substrate for the continuous monitoring of HCV NS3 protease activity.	price>
R-M-508	Ac-Asp-Glu-Val-Asp-AFC	Ac-Asp-Glu-Val-Asp-AFC (Ac-DEVD-AFC) is a sensitive fluorescent substrate for the assay of caspase-3 activity. The trifluoromethyl substituent of the fluorophore improves the membrane permeability of the substrate.	price>
R-M-510	Ac-DEVD-AMC	Ac-DEVD-AMC(CAS :169332-61-0) is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.	price>
R-M-512	Ac-Asp-Glu-Val-Asp-pNA	Ac-Asp-Glu-Val-Asp-pNA,Ac-DEVD-pNA(CAS : 189684-50-2) from ruixi.The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm.	price>
R-M-513	Ac-Asp-Met-Gln-Asp-AMC	Ac-Asp-Met-Gln-Asp-AMC is a fluorogenic substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery. Ac-DMQD-AMC is reported to be a more specific caspase-3 substrate than Ac-DEVD-AMC.	price>
R-M-525	Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide	Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH₂ trifluoroacetate salt(CAS:400716-78-1),Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide from ruixi. Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide, a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme can degrade extracellular matrix components and may facilitate the spread of tumor cells. High levels of active cathepsin D were found within senile plaques in brains of Alzheimer patients.	price>
R-M-526	Ac-Glu-Glu-Val-Val-Ala-Cys-pNA	Ac-EEVVAC-pNA, chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. The sequence EEVVAC is derived from the 5A-5B cleavage junction of the HCV polyprotein.	price>

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