Product peptide-substrate-peptide

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Catalog	name	Description	price
R-M-196	Ser25 PKC [19-31] Peptide	This is a peptide derived from the pseudosubstrate regulatory domain of PKC α residues (19-31) with alanine being replaced with serine at position 25.This peptide is a pseudosubstrate for a number of serine/threonine kinases, including protein kinase A (PKA), protein kinase B (PKB), protein kinase C (PKC), protein kinase CHK1, and glycogen synthase kinase 3 (GSK3) different isoforms. The peptide sequence is derived from the residues 19-31 of human protein kinase C isoforms alpha and beta, which contains the R-X-X-S/T consensus motif for Ser/Thr kinases that phosphorylate the Ser25 within this peptide.	price>
R-M-156	Tyrosine Protein Kinase Substrate Peptide	This peptide is a substrate for tyrosine protein kinases such as EGFR and Src subfamily members. The sequence derives from the residues 412-422 of the Tyr-419 tyrosine autophosphorylation site of the proto-oncogene tyrosine protien kinase Src (c-Src).	price>
R-M-197	S6 Kinase Substrate [229-239] Peptide	Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents and mitogens and the dephosphorylation by growth arrest. The 229-239 peptide contain two phosphorylation sites, Ser235 and Ser236.	price>
R-M-198	KL-1 Peptide	KL-1 Peptide corresponds to aa 185-196 of Kit Ligand (KITLG, KL) also known as Stem Cell Factor (SCF). A soluble form (sKITLG) is produced by proteolytic processing of transmembrane KITLG at aa190. KL-1 peptide is used as a substrate for proteases such as furin. SCF stimulates the proliferation of mast cells, augments the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture, and mediates cell-cell adhesion. SCF acts synergistically with other cytokines such as interleukins.	price>
R-M-199	Elastase Substrate Peptide	This peptide is a fluorogenic substrate for elastase, a peptidase S1 family member that cleaves at Ala-Xaa sites within proteins, including elastin. The peptide is labeled with rhodamine 110, a highly fluororescent dye upon substrate cleavage (Abs/Em = 497/520 nm).	price>
R-M-200	Cathepsin L Substrate Peptide	This peptide is a fluorogenic substrate for cathepsin L and plasmin, peptidase C1 family members that cleave at Arg-Xaa and Lys-Xaa sites within proteins. The peptide is labeled with rhodamine 110, a highly fluororescent dye upon substrate cleavage (Abs/Em = 497/520 nm).	price>
R-M-201	CaMKII Substrate Peptide	This peptide is a substrate (Km = 7.5 mM) for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the residues 1-10 of the glycogen synthase containing a phosphorylation site at Ser-7 within the R-X-X-S/T consensus site and is amidated at the C-terminus end. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Phosphorylation of the substrate is calcium and calmodulin dependent.	price>
R-M-202	Calcineurin Substrate Peptide	The calcineurin substrate peptide corresponds to a sequence from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate can be used for assaying protein phosphatase-2B (calcineurin) activity.	price>
R-M-203	Autocamtide-2 Peptide	Autocamtide-2 is a highly selective peptide substrate for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the Thr-286 autophosphorylation site of the alpha subunit of CaMKII. Autocamtide-2 contains the R-X-X-S/T consensus site surrounded by basic residues for improved binding to phosphocellulose. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CaMKII phosphorylates Autocamtide-2 with a Km of 2 uM whereas protein kinase C (PKC) has a Km > 50 uM and protein kinase A (PKA) has no activity.	price>
R-M-204	CREBtide Peptide	This eptide is a synthetic substrate for protein kinase A (PKA) with a Km = 3.9 uM. The peptide sequence corresponds to residues 123-135 of human cAMP-response element-binding protein (CREB) and contains the Ser-133 phosphorylation site for CaMK1, CaMK2 and CaMK4.	price>

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