Ac-Asp-Met-Gln-Asp-AMC

Ac-Asp-Met-Gln-Asp-AMC is a fluorogenic substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery. Ac-DMQD-AMC is reported to be a more specific caspase-3 substrate than Ac-DEVD-AMC.

MSDS of Ac-Asp-Met-Gln-Asp-AMC