Product phospholipids -phospholipid-peg-customization

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Catalog	name	Description	price
R-DS-0098	DSPE-PEG-FGF-21	A modified human FGF-21 polypeptide consists of SEQ ID No: 1,SEQ ID No: 2,SEQ ID No: 3,SEQ ID No: 4 with methionine fused at the N-terminal,SEQ ID No: 5,SEQ ID No: 6 or SEQ ID with methionine fused at the N-terminal The modified human FGF-21 peptide has the biological activity of at least one FGF-21,and the unnatural coding amino acid is selected from para substituted phenylalanine,ortho substituted phenylalanine and meta substituted phenylalanine.	price>
R-DS-1111	DSPE-PEG-PTP(KTLLPTP)	PTP (ktllptp) specifically binds to pancreatic cancer cells.Proteomic analysis showed that PTP was targeted by specifically binding to plectin-1,which was mistakenly located on the cell membrane surface during the occurrence of pancreatic cancer.	price>
R-DS-0099	DSPE-PEG-ApoL1	APOL1 encodes a secreted high density lipoprotein(apolipoprotein L1) which binds to apolipoprotein A-I.Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL.It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body,as well as in reverse cholesterol transport from peripheral cells to the liver.Several different transcript variants encoding different isoforms have been found for APOL1.	price>
R-DS-0100	GRF-PEG-DSPE	Growth hormone releasing factor (GRF),also known as growth hormone releasing hormone (GHRH),is a kind of bioactive polypeptide existing in vertebrates.It is synthesized and secreted by hypothalamus and plays an important role in the growth,development and metabolism of vertebrates,As a positive regulator of pituitary growth hormone (GH),it can specifically induce the synthesis and secretion of growth hormone,and increase the level of GH in animal organs.	price>
R-DS-0101	T-20-PEG-DSPE	Like other peptide drugs,T-20 also has short half-life and poor stability in vivo.In order to obtain anti AIDS polypeptide with long efficacy and high stability,the peptide drug T-20 was modified by PEG (polyethylene glycol) and glycosylation by introducing selective amino acid sites(Cys SH) into the non active domain of the peptide through chemical synthesis,combined with organic synthesis and enzymatic synthesis technology.	price>
R-C-0102	DSPE-PEG2000-RVG29PPP(D-RVG29)	Rabies virus is a natural neurotropic virus.Its capsid contains a neurogenic protein (RVG),which can be specifically recognized by the nicotinic acetylcholine receptor (nAChR) on the surface of nerve cells.Under the action of RVG,rabies virus can easily cross the blood-brain barrier,invade brain tissue and sacred center,and cause rabies,The 29 amino acid sequence of RVG29 (YTIWMPENPRPGTPCDIFTNSRGKRASNG) can also be specifically recognized by nAChR.Liu et al.and Gong et al.T bonded RVG29 to polyamide amine dendrimer (PAMAM) and poly (ethylene amine) (PEI) to support and transport nucleic acid drugs,PAMAM and PE modified by RVG29 could pass through the BBB model,but could deliver cytotoxic anticancer drugs to pus.	price>
R-C-0103	DSPE-PEG2000-OME(D-OME)	To study the targeting effect of a novel ligand RVG29 modified liposome on gliomas in vitro.DSPE-PEG2000-RVG29 PPP (D-RVG29) was prepared by organic phase synthesis method,and liposomes were prepared by membrane dispersion method,The addition of DSPE-PEG2000-OME (D-OME) into the liposome formulation can make D-RVG29 modified liposomes have better particle size and distribution range.The uptake of D-RVG29 modified liposomes by C6 cells is stronger than that of unmodified d-rvg29 liposomes.There is no significant difference in the uptake intensity of the two liposomes by HeLa cells.D-OME can improve the stability of D-RVG29 modified liposomes,D-RVG29 modified liposome has the targeting ability of glioma cells in vitro.	price>
R-DS-0012	DSPE-PEG-THRPPMWSPVWP	Liposomes have the advantages of low toxicity,easy preparation,and can be used as the carrier of water-soluble drugs and lipid soluble drugs.It can be used in a variety of drug delivery routes,improve the stability of drugs and achieve targeted drug delivery.However,when liposomes enter the body,due to the specific conditioning effect of plasma opsonin on liposomes and the nonspecific hydrophobic interaction between reticuloendothelial system (RES) cells and liposomes,it is easy to be absorbed and cleared by res cells.The half-life of liposomes in blood circulation is short (generally 30 min),and its active targeting and stability are poor,so its application is limited.	price>
R-DS-0013	DSPE-PEG-FSHB	Follicle stimulating hormone (FSH) and its receptor (FSHR) binding fragment fshb (qchcgkcdsdstdct,fshl81-95),a peptide fragment of FSH,was used as a targeting head group J.the constructed FSHR targeting drug delivery system had good targeting effect on FSHR positive ovarian cancer cells.	price>
R-DS-0014	DSPE-PEG-NYZL1（Asn-Tyr-Glx-Leu）	The polypeptide nyzl1 (ASN Tyr GLX Leu) can specifically bind to bladder cancer tissues and cells,and has significant binding specificity.	price>

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