Product phospholipids -phospholipid-peg-customization

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Catalog	name	Description	price
R-DS-0055	DSPE-PEG-PVTRPPR	PVTRPPR was modified on the surface of stealth liposomes,and pvtrppr polypeptide was used as the targeting head group.The drug loaded stealth liposome could target the drug to the tumor blood vessels through the tumor penetrating peptide pvtrppr,and penetrate the whole tumor tissue directly,so as to improve the therapeutic effect of the drug.	price>
R-DS-0056	DSPE-PEG-T7(HAIYPRH)	T7(HAIYPRH) is a short peptide screened by phage display technology,which can specifically bind to TfR with a binding constant as high as 10 nmol·L −1. Moreover,due to the different binding sites,endogenous TF will not inhibit, but will promote the binding of T7 modified nanoparticles to TfR.Therefore,T7 is more suitable as a target molecule,and there are many reports on the application of T7 peptide alone.	price>
R-DS-0057	DSPE-PEG-R9	Cell penetrating peptide (CPP) is a kind of short peptide with strong penetration effect on cell membrane,which can promote cell uptake.Liposome modified by CPP can improve the rate of liposome entry into the cell,which is a new direction of targeted drug delivery carrier research.	price>
R-DS-0058	DSPE-PEG-ADH1	Liposomes can passively enter tumor tissue through enhanced retention and retention effect(EPR).Compared with radiotherapy and chemotherapy alone, liposomes have certain clinical treatment advantages.However,the liposome can not reach the target site immediately after injection and stay at the tumor site for a long time.	price>
R-DS-0059	DSPE-PEG3400-SPA	Peptide is a compound formed by α-amino acids linked together by peptide bond, which is the intermediate product of protein hydrolysis.Peptides are widely used in medical research,drug release,nanotechnology and new materials research,cell culture.And the active compounds such as ligand research,peptide synthesis support,graft polymer,new materials and polyethylene glycol modified functional coating.	price>
R-DS-0060	PH1-PEG-DSPE	To verify the potential of targeting distribution of peptide guided liposome drug delivery system,the peptide can be coupled to the polyethylene glycol end of DSPE-PEG through the specific reaction between the sparse group and the maleimide group through the linker SPDP,and the linked products were analyzed by HPLC. We used post insertion technique to combine ph1-peg-dspe micelles with liposomes（ HSPC:Chol Methods:DSPE-PEG=2:1:0.1) were co incubated to prepare targeted liposomes.However,the expression of phe2 in tumor cells was higher by Lipofectamine conjugation and liposome conjugation.Ph1 coupled with cisplatin loaded long circulating liposomes can greatly improve the cytotoxicity of cisplatin liposomes to Tie2 positive cells.	price>
R-DS-0061	DSPE-PEG-TxID	Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs.Peptide carrier targeting technology is known as a new generation of targeted drug development technology.	price>
R-DS-0062	DSPE-PEG-TR	The active and passive DSPE-PEG micelles containing coumarin-6 were constructed by linking tr peptide with DSPE-PEG.After that,we separated glioma stem cells by fluorescence activated immune cell sorting method and tumor ball culture method. By confocal microscopy and flow cytometry,the uptake of TR modified micelles by tumor stem cells was increased,which proved that tr modified micelles were targeted in vitro.	price>
R-DS-0063	DSPE-PEG-VAP	As a somatostatin analogue,VAP is used as a modifier of tumor targeting delivery system because of its high affinity with somatostatin receptor.Dspe-peg-vap was prepared by chemical coupling of α-NH2 of D-phenylalanine with nhs-pegdspe, and then modified paclitaxel loaded nano micelle delivery system with dspe-peg-vap.	price>
R-DS-0064	c(RGDDYK)-PEG3400-DSPE	c(RGDDYK) is a model peptide targeting molecule,which can be modified on the surface of liposomes.The immunogenicity and related mechanism of peptide mediated targeting nanoparticles were systematically studied.After intravenous injection of c(RGDDYK) modified liposomes,a large number of antibodies were produced. Repeated injections resulted in the deposition of immune complexes with antibodies in liver,kidney and lung tissues,activating the complement system, releasing allergens and cytokines,resulting in hypersensitivity such as capillary leakage,alveolar protein deposition,inflammatory cell infiltration,kidney and liver congestion,resulting in hypothermia or death in mice.	price>

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