Product phospholipids -phospholipid-peg-customization

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Catalog	name	Description	price
R-DS-0058	DSPE-PEG-ADH1	Liposomes can passively enter tumor tissue through enhanced retention and retention effect(EPR).Compared with radiotherapy and chemotherapy alone, liposomes have certain clinical treatment advantages.However,the liposome can not reach the target site immediately after injection and stay at the tumor site for a long time.	price>
R-DS-0059	DSPE-PEG3400-SPA	Peptide is a compound formed by α-amino acids linked together by peptide bond, which is the intermediate product of protein hydrolysis.Peptides are widely used in medical research,drug release,nanotechnology and new materials research,cell culture.And the active compounds such as ligand research,peptide synthesis support,graft polymer,new materials and polyethylene glycol modified functional coating.	price>
R-DS-0060	PH1-PEG-DSPE	To verify the potential of targeting distribution of peptide guided liposome drug delivery system,the peptide can be coupled to the polyethylene glycol end of DSPE-PEG through the specific reaction between the sparse group and the maleimide group through the linker SPDP,and the linked products were analyzed by HPLC. We used post insertion technique to combine ph1-peg-dspe micelles with liposomes（ HSPC:Chol Methods:DSPE-PEG=2:1:0.1) were co incubated to prepare targeted liposomes.However,the expression of phe2 in tumor cells was higher by Lipofectamine conjugation and liposome conjugation.Ph1 coupled with cisplatin loaded long circulating liposomes can greatly improve the cytotoxicity of cisplatin liposomes to Tie2 positive cells.	price>
R-DS-0061	DSPE-PEG-TxID	Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs.Peptide carrier targeting technology is known as a new generation of targeted drug development technology.	price>
R-DS-0062	DSPE-PEG-TR	The active and passive DSPE-PEG micelles containing coumarin-6 were constructed by linking tr peptide with DSPE-PEG.After that,we separated glioma stem cells by fluorescence activated immune cell sorting method and tumor ball culture method. By confocal microscopy and flow cytometry,the uptake of TR modified micelles by tumor stem cells was increased,which proved that tr modified micelles were targeted in vitro.	price>
R-DS-0063	DSPE-PEG-VAP	As a somatostatin analogue,VAP is used as a modifier of tumor targeting delivery system because of its high affinity with somatostatin receptor.Dspe-peg-vap was prepared by chemical coupling of α-NH2 of D-phenylalanine with nhs-pegdspe, and then modified paclitaxel loaded nano micelle delivery system with dspe-peg-vap.	price>
R-DS-0064	c(RGDDYK)-PEG3400-DSPE	c(RGDDYK) is a model peptide targeting molecule,which can be modified on the surface of liposomes.The immunogenicity and related mechanism of peptide mediated targeting nanoparticles were systematically studied.After intravenous injection of c(RGDDYK) modified liposomes,a large number of antibodies were produced. Repeated injections resulted in the deposition of immune complexes with antibodies in liver,kidney and lung tissues,activating the complement system, releasing allergens and cytokines,resulting in hypersensitivity such as capillary leakage,alveolar protein deposition,inflammatory cell infiltration,kidney and liver congestion,resulting in hypothermia or death in mice.	price>
R-DS-0065	LyP-1-PEG3400-DSPE	Cyclopeptide LyP-1 modified liposomes:polypeptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs. It has also been proved by experiments that it can enhance the targeting specificity of drugs,enhance the targeted absorption of drugs,improve the anti-tumor effect,and at the same time,it can improve the original insoluble properties of some small molecule drugs.Peptide carrier targeting technology is known as a new generation of targeted drug development technology.	price>
R-DS-0066	c(RGDyK)-pHA-PEG-DSPE	Peptide mediated targeting drug nanopreparation is an active targeting drug preparation which introduces peptide targeting molecules onto the surface of nano carriers.It can increase the amount of drugs reaching tumor tissue and tumor cells,and achieve the goal of effective treatment of tumor.c(RGDyK) was used as a model peptide targeting molecule,which could be modified on the surface of liposomes.The immunogenicity and related mechanism of peptide mediated targeting nanoparticles were systematically studied.	price>
R-DS-0067	MC-DA7R-PEG-DSPE	MC-DA7R-PEG-DSPE liposome delivery system can transport BBB and BBTB, target glioma cells,stem cells and tumor neovascularization.After doxorubicin was loaded,MC-DA7R-PEG-DSPE liposomes could effectively inhibit tumor angiogenesis and pseudo angiogenesis,promote apoptosis of glioma cells,and reduce the number of glioma stem cells,thus enhancing the anti glioma effect of doxorubicin.The median survival time of the model animals was longer than that of single targeted molecular modified liposomes (MC-PEG-DSPE liposome and DA7R-PEG-DSPE liposome) 63.6% and 38.5% respectively.	price>

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