DSPE-PEG2000-D4

Peptide ligands containing six amino acids were screened for tumor cell epidermal growth factor (EGFR).Fluorescent liposomes containing D4 peptide were injected into tumor bearing mice via tail vein.In vivo imaging of small animals showed that fluorescent liposomes not only accumulated in tumor,but also had strong fluorescence signal in brain.Using loperamide as the"probe"and DSPE-PEG2000-D4 micelles as carriers,we found that D4 peptide has the ability to cross the blood-brain barrier through hot water bath tail contraction and formalin induced pain in mice.

MSDS---DSPE-PEG2000-D4