Product phospholipids -phospholipid-peg-customization

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Catalog	name	Description	price
R-DS-0045	DSPE-PEG3400-RGERPPR	DSPE conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol,which has hydrophilicity and hydrophobicity.Polyethylene glycol phospholipid liposomes can be used for drug delivery,gene transfection and vaccine delivery.Pegylated phospholipids can significantly improve blood circulation time and stabilize drug encapsulation.These materials can also be used for targeted drug delivery by modifying ligands with target surfaces such as antibodies and peptides.	price>
R-DS-0046	DSPE-PEG-c(RGDyK)	The immunogenicity of C (rgdyk)-peg-dspe was derived from C (rgdyk)-peg-dspe, which eventually led to serious life-threatening toxicity.However,C(rgdyk) itself had no ability to induce immune response.The results of antibody typing showed that IgG3 was the main subtype of specific IgG antibody of C (rgdyk) modified liposomes,and the antibody production rate was fast,suggesting that C (rgdyk) modified liposomes belonged to T cell independent type-2 (TI-2) antigen. At the same time,it was found that cytotoxic chemotherapeutic drugs could mask the immunogenicity of C (rgdyk) modified liposomes,but there might be safety problems when they were used to deliver molecular targeted drugs with good tumor cell specificity and low adverse reactions in normal tissues.	price>
R-DS-0047	DSPE-PEG-iNGR(CRNGRGPDC)	LPNs were prepared with poly (histidine)(PHIS) as the core and di stearyl phosphatidylethanolamine polyethylene glycol (DSPE-PEG) and lecithin (EPC) as the single-layer shell.The anti-tumor drug DOX was encapsulated in LPNs and modified with the peptide ingr (crngrgpdc).	price>
R-DS-0048	DSPE-PEG-NGR(ASP-Gly-Arg)-CD13	Polyethylene glycol phospholipid liposomes can be used for drug delivery,gene transfection and vaccine delivery.Polyethylene glycol phosphowax can significantly improve the blood circulation time and stabilize the drug package. These materials can also be used for targeted drug delivery by modifying surface ligands such as antibodies and peptides.The targeting peptide can target CD13 receptor which is over expressed in tumor neovascularization epithelial cells.	price>
R-DS-0049	DSPE-PEG-FAL	Non lysosomal cationic liposomes modify common cationic liposomes by introducing special fal peptides.Firstly,the product dspe-pec-fal was obtained by modifying dspe-peg-nh2 with fl polypeptide.The results of NMR and IR showed that the Al peptide was successfully connected to dspe-pec.Cationic lipid 2-dioleoylhydropropyl-3-n,N,k-trimethylammonium (DOTAP) was selected as cationic lipid,Liposomes modified by fal were prepared by film dispersion method using neutral auxiliary lipid dioleoyl phosphatidylethanolamine (DOPE) and the mixture of DSPE-PEC-NH2 and DSPE-PEG-FAL.	price>
R-DS-0050	DSPE-PEG2000-D4	Peptide ligands containing six amino acids were screened for tumor cell epidermal growth factor (EGFR).Fluorescent liposomes containing D4 peptide were injected into tumor bearing mice via tail vein.In vivo imaging of small animals showed that fluorescent liposomes not only accumulated in tumor,but also had strong fluorescence signal in brain.Using loperamide as the"probe"and DSPE-PEG2000-D4 micelles as carriers,we found that D4 peptide has the ability to cross the blood-brain barrier through hot water bath tail contraction and formalin induced pain in mice.	price>
R-DS-0051	DSPE-PEG2000-RLT	Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs.	price>
R-DS-0052	DSPE-PEG5000-LTV	On the basis of PL(ID)NP nanoparticles,pl(V/D) np-ltv,a dual-mode CT/fluorescence nanoparticles targeting spontaneous breast cancer,was developed.HER2 targeted nanoparticles pl(I/D) np-ltv were prepared by modifying pl(I/D) NP with targeted phospholipid dspe-peg5000-ltv.The particle size of DLS was 64.9 ± 1.3 nm and had good serum stability.	price>
R-DS-0053	RPAKPAR-PEG-DSPE	A variety of receptors are highly expressed in brain tumor cells and blood-brain barrier,such as transferrin receptor,low-density lipoprotein receptor and so on. Therefore,the specific ligands of these receptors can be used as two-level target molecules for blood-brain barrier and brain tumor cells.	price>
R-DS-0054	DSPE-PEG2000-NGF	NGF is a kind of polypeptide with various activities,which widely exists in various tissues of animals.It can nourish the injured peripheral nerve and promote regeneration and repair.When the peripheral nerve is injured,its corresponding cell body and axon can use exogenous NGF to transport retrogradely through the injured axon,making NGF reach the corresponding cell body.After the complex process of anabolism,NGF can be extended,It promotes axonal myelination.	price>

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