Product apis-nf-kb

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Catalog	name	Description	price
R-R-1329	Mangiferin CAS No.4773-96-0	Mangiferin/CAS No.4773-96-0 is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities.	price>
R-R-1330	Mollugin CAS No.55481-88-4	Mollugin/CAS No.55481-88-4 is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway.	price>
R-R-1331	JAK-IN-23	JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD).	price>
R-R-1332	Dauricine CAS No.524-17-4	Dauricine/CAS No.524-17-4, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.	price>
R-R-1333	Micheliolide CAS No.68370-47-8	Micheliolide/CAS No.68370-47-8 could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).	price>
R-R-1334	Taraxerol CAS No.127-22-0	Taraxerol/CAS No.127-22-0 is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis.	price>
R-R-1335	Asatone CAS No.38451-63-7	Asatone/CAS No.38451-63-7 is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.	price>
R-R-1336	Guaiacol-d3 CAS No.74495-69-5	Guaiacol-d3/CAS No.74495-69-5 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity.	price>
R-R-1337	Ginsenoside Re CAS No.52286-59-6	Ginsenoside Re (Ginsenoside B2)/CAS No.52286-59-6 is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.	price>
R-R-1338	(R)-(-)-Ibuprofen-d3 CAS No.121702-86-1	(R)-(-)-Ibuprofen-d3/CAS No.121702-86-1 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.	price>

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