Product peptide-blocking-peptide

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Catalog	name	Description	price
R-M-185	WNK4 Peptide	Ser/Thr-protein kinase WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation, which prevents membrane trafficking of SLC12A3. WNK4 also inhibits the renal potassium channel KCNJ1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. WNK4 is exclusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. Defects in WNK4 are a cause of pseudohypoaldosteronism type II (PHAII).	price>
R-M-186	VHL Peptide	VHL,Von Hippel Lindau is involved in the ubiquitination and subsequent proteasomal degradation of hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Defects in VHL are the cause of different types of cancers (pheochromocytoma, von Hippel-Lindau disease) and erythrocytosis.	price>
R-M-187	TYRO10 (DDR2) Peptide	TYRO10 (DDR2)Peptide,TYRO10(Discoidin Domain Receptor Tyrosine Kinase 2)Peptidefrom ruixi.TYRO10 (DDR2),Discoidin Domain Receptor Tyrosine Kinase 2 is a tyrosine kinase receptor for fibrillar collagen that mediates fibroblast migration and proliferation. TYRO10 contributes to cutaneous wound healing.	price>
R-M-154	XPC Peptide	Xeroderma pigmentosum group C-complementing protein (XPC) is involved in DNA excision repair by recognizing DNA damage and altering chromatin structure for damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C characterized by solar sensitivity and skin cancer predisposition.	price>
R-M-279	TNF-alpha	Tumor necrosis factor alpha (TNF-alpha) is a cytokine that binds to the TNF-R1 and TNF-R2 receptors. TNF-alpha is mainly secreted by macrophages and induces cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion, and therefore found in cachexia accompanying diverse cancers and infections. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and to HBV infection.	price>
R-M-281	TIMP-3 Peptide	Tissue inhibitor of metalloproteinases 3 (TIMP-3) binds to metalloproteinases such as collagenases and irreversibly inactivates the proteases. TIMP-2 is involved in the extracellular matrix remodeling by binding to MMP-1, -2, -3, -7, -9, -13, -14 and -15. Defects in TIMP-3 are the cause of Sorsby fundus dystrophy (SFD), a macular disorder leading to vision loss.	price>
R-M-1266	SYVN1 Peptide	Synoviolin (SYVN1) acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates subsequently promoting their degradation. For instance, SYVN1 protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. SYVN1 is up-regulated in synovial tissues from patients with rheumatoid arthritis.	price>
R-M-1267	SUMO2/3 Peptide	SUMO2 and SUMO3 are ubiquitin-like proteins which can be covalently attached to target lysines as a monomer. SUMO proteins play a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.	price>
R-M-1268	SUMO1 Peptide	SUMO1 is an ubiquitin-like protein which can be covalently attached to target lysines as a monomer. SUMO1 plays a role in a number of cellular processes such as nucle.	price>
R-M-1269	SUFU Peptide	SUFU is a negative regulator in the hedgehog signaling pathway that down-regulates GLI1-mediated transactivation of target genes. Defects in SUFU are a cause of medulloblastoma, a malignant and invasive embryonal tumor of the cerebellum.	price>

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