Product apis-apoptosis

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Catalog	name	Description	price
R-R-2027	Famitinib CAS No.1044040-56-3	Famitinib (SHR1020)/CAS No.1044040-56-3, an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively. Famitinib exerts powerful antitumor activity in human gastric cancer cells and xenografts. Famitinib triggers apoptosis.	price>
R-R-2028	JNJ-1013 CAS No.2597343-08-1	JNJ-1013/CAS No.2597343-08-1 is a potent and selective IRAK1 degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705).	price>
R-R-2029	Rotundifuran CAS No.50656-65-0	Rotundifuran/CAS No.50656-65-0, a labdane type diterpene, is isolated from Vitex rotundifolia. Rotundifuran can inhibit the cell cycle progression and induce apoptosis in human myeloid leukaemia cells.	price>
R-R-2030	PIM447 CAS No.1210608-43-7	PIM447 (LGH447)/CAS No.1210608-43-7 is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis.	price>
R-R-2031	SKLB4771 CAS No.1370256-78-2	SKLB4771/CAS No.1370256-78-2 is a potent and selective Flt3 inhibitor with an IC50 value of 10 nM. SKLB4771 downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue.	price>
R-R-2032	Tigatuzumab CAS No.918127-53-4	Tigatuzumab (CS-1008)/CAS No.918127-53-4 is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer.	price>
R-R-2033	Swainsonine CAS No.72741-87-8	Swainsonine (Tridolgosir)/CAS No.72741-87-8 is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.	price>
R-R-2034	Bomedemstat ditosylate CAS No.1990504-72-7	Bomedemstat (IMG-7289) ditosylate/CAS No.1990504-72-7 is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis.	price>
R-R-2035	SM-1295 CAS No.1562375-46-5	SM-1295/CAS No.1562375-46-5 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively.	price>
R-R-2036	Oxcarbazepine CAS No.28721-07-5	Oxcarbazepine/CAS No.28721-07-5 is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.	price>

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