Product apis-apoptosis

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Catalog	name	Description	price
R-R-1987	Etoposide phosphate CAS No.117091-64-2	Etoposide phosphate (BMY-40481)/CAS No.117091-64-2 is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.	price>
R-R-1988	L-Cystathionine CAS No.56-88-2	L-Cystathionine/CAS No.56-88-2 is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.	price>
R-R-1989	MY-875	MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity.	price>
R-R-1990	PFK-158 CAS No.1462249-75-7	PFK-158/CAS No.1462249-75-7 is an effective selective PFKFB3 inhibitor with an IC50 value of 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces cancer cell apoptosis and autophagy. PFK-158 has a wide range of anti-tumor activities. PFK-158 can also enhance the resistance of colistin to bacteria.	price>
R-R-1991	Lactonic sophorolipid CAS No.148409-20-5	Lactonic sophorolipid/CAS No.148409-20-5 is a natural antimicrobial surfactant for oral hygiene. Lactonic sophorolipid, a potential anticancer agent, induces apoptosis in human HepG2 cells through the caspase-3 pathway.	price>
R-R-1992	MSN-125 CAS No.1592908-16-1	MSN-125/CAS No.1592908-16-1 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.	price>
R-R-1993	Ro 41-5253 CAS No.144092-31-9	Ro 41-5253/CAS No.144092-31-9 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity.	price>
R-R-1994	M50054 CAS No.54135-60-3	M50054/CAS No.54135-60-3 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia.	price>
R-R-1995	Nur77 modulator 1 CAS No.2469975-55-9	Nur77 modulator 1/CAS No.2469975-55-9 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity.	price>
R-R-1996	Delphinidin chloride CAS No.528-53-0	Delphinidin chloride/CAS No.528-53-0, an anthocyanidin, is isolated from berries and red wine. Delphinidin chloride shows endothelium-dependent vasorelaxation. Delphinidin chloride also can modulate JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells.	price>

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