Product apis-apoptosis

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Catalog	name	Description	price
R-R-1977	CPTH2 CAS No.357649-93-5	CPTH2/CAS No.357649-93-5 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B).	price>
R-R-1978	Almorexant CAS No.871224-64-5	Almorexant (ACT 078573)/CAS No.871224-64-5 is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.	price>
R-R-1979	Isatuximab CAS No.1461640-62-9	Isatuximab/CAS No.1461640-62-9 is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions.	price>
R-R-1980	MG-101 CAS No.110044-82-1	MG-101 (ALLN)/CAS No.110044-82-1 is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.	price>
R-R-1981	Ceranib-2 CAS No.1402830-75-4	Ceranib-2/CAS No.1402830-75-4 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity.	price>
R-R-1982	Tricetin CAS No.520-31-0	Tricetin/CAS No.520-31-0 is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in the Parkinsonism model by activating the Nrf2/HO-1 signaling pathway and preventing the mitochondria-dependent apoptosis pathway.	price>
R-R-1983	1G244 CAS No.847928-32-9	1G244/CAS No.847928-32-9 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.	price>
R-R-1984	Apoptolidin CAS No.194874-06-1	Apoptolidin/CAS No.194874-06-1 is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells.	price>
R-R-1985	TL4-12 CAS No.1620820-12-3	TL4-12/CAS No.1620820-12-3 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM).	price>
R-R-1986	HLI373 dihydrochloride CAS No.1782531-99-0	HLI373 dihydrochloride/CAS No.1782531-99-0 is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents. Antimalarial activity.	price>

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