Product apis-apoptosis

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Catalog	name	Description	price
R-R-1956	Loncastuximab tesirine CAS No.1879918-31-6	Loncastuximab tesirine/CAS No.1879918-31-6 is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma.	price>
R-R-1957	SB-218078 CAS No.135897-06-2	SB-218078/CAS No.135897-06-2 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest.	price>
R-R-1958	Periplocin CAS No.13137-64-9	Periplocin/CAS No.13137-64-9 is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase.	price>
R-R-1959	AS-99 TFA	AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo.	price>
R-R-1960	ADH-6 TFA	ADH-6 TFA is a tripyridylamide compound. The self-assembly of the aggregated nucleonic domain of the mutant p53 DBD was abolished by ADH-6. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, thereby restoring p53 transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential to study cancer diseases.	price>
R-R-1962	A-192621 CAS No.195529-54-5	A-192621/CAS No.195529-54-5 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level.	price>
R-R-1963	Thienopyridone CAS No.1018454-97-1	Thienopyridone/CAS No.1018454-97-1 is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects.	price>
R-R-1964	NSC348884 CAS No.81624-55-7	NSC348884/CAS No.81624-55-7 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer.	price>
R-R-1965	SIRT6 activator 12q CAS No.2601734-99-8	SIRT6 activator 12q/CAS No.2601734-99-8 is potent, selective and orally active SIRT6 activator with IC50 values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity.	price>
R-R-1966	Hypericin CAS No.548-04-9	Hypericin/CAS No.548-04-9 is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis.	price>

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