Product apis-apoptosis

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Catalog	name	Description	price
R-R-1836	LCH-7749944 CAS No.796888-12-5	LCH-7749944 (GNF-PF-2356)/CAS No.796888-12-5 is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.	price>
R-R-1837	Benzoylpaeoniflorin CAS No.38642-49-8	Benzoylpaeoniflorin/CAS No.38642-49-8, a natural product from Chinese paeony root, has the potential for coronary heart disease by decreasing apoptosis.	price>
R-R-1838	Polyphyllin I CAS No.50773-41-6	Polyphyllin I/CAS No.50773-41-6 is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.	price>
R-R-1839	Thiocolchicine CAS No.2730-71-4	Thiocolchicine/CAS No.2730-71-4, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.	price>
R-R-1840	Falcarinol CAS No.21852-80-2	Falcarinol (Panaxynol)/CAS No.21852-80-2 is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis. Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-1841	Etalocib CAS No.161172-51-6	Etalocib (LY293111)/CAS No.161172-51-6, an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis.	price>
R-R-1842	Ursonic acid CAS No.6246-46-4	Ursolic acid/CAS No.6246-46-4, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways.	price>
R-R-1843	Trametinib-13C,d3 CAS No.2712126-59-3	Trametinib-13C,d3/CAS No.2712126-59-3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis.	price>
R-R-1844	PARP14 inhibitor H10 CAS No.2084811-68-5	PARP14 inhibitor H10/CAS No.2084811-68-5, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.	price>
R-R-1845	Eftozanermin alfa CAS No.1820660-69-2	Eftozanermin alfa (ABBV-621)/CAS No.1820660-69-2 is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies.	price>

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