Product apis-apoptosis

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Catalog	name	Description	price
R-R-1826	RIPGBM CAS No.355406-76-7	RIPGBM/CAS No.355406-76-7 is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM.	price>
R-R-1827	TCS PrP Inhibitor 13 CAS No.34320-83-7	TCS PrP Inhibitor 13/CAS No.34320-83-7, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis.	price>
R-R-1828	5,6-Dichlorobenzimidazole riboside CAS No.53-85-0	5,6-Dichlorobenzimidazole riboside (DRB)/CAS No.53-85-0 is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis.	price>
R-R-1829	SKLB325	SKLB325 is a Jumonji domain-containing 6 (JMJD6) inhibitor with a binding affinity (KD) value of 0.755 μM, and the IC50 value of 0.7797 μM. SKLB325 exhibits antitumor effects on ovarian cancer in vivo and in vitro. SKLB325 induces apoptosis. SKLB325 exhibits remarkable antitumor efficacy in renal cell carcinoma (RCC) .	price>
R-R-1830	AG-024322 CAS No.837364-57-5	AG-024322/CAS No.837364-57-5 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range. AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation in vivo. AG-024322 induces cell apoptosis.	price>
R-R-1831	Hesperetin CAS No.520-33-2	Hesperetin/CAS No.520-33-2 is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.	price>
R-R-1832	STAT3-IN-1 CAS No.2059952-75-7	STAT3-IN-1 (compound 7d)/CAS No.2059952-75-7 is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis.	price>
R-R-1833	PARP10/15-IN-3 CAS No.2892064-88-7	PARP10/15-IN-3 (Compound 8a)/CAS No.2892064-88-7 is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.14 µM and 0.40 µM against PARP10 and PARP15, respectively. PARP10/15-IN-3 is able to enter cells and rescue cells from apoptosis.	price>
R-R-1834	PARP10/15-IN-2 CAS No.2892064-99-0	PARP10/15-IN-2 (Compound 8h)/CAS No.2892064-99-0 is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.15 µM and 0.37 µM against PARP10 and PARP15, respectively. PARP10/15-IN-2 is able to enter cells and rescue cells from apoptosis.	price>
R-R-1835	Coenzyme Q9 CAS No.303-97-9	Coenzyme Q9 (Ubiquinone Q9)/CAS No.303-97-9, the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis.	price>

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