Product apis-apoptosis

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Catalog	name	Description	price
R-R-1816	Sappanchalcone CAS No.94344-54-4	Sappanchalcone/CAS No.94344-54-4, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells.	price>
R-R-1817	Adarotene CAS No.496868-77-0	Adarotene/CAS No.496868-77-0 is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.	price>
R-R-1818	MitoTam iodide, hydriodide CAS No.1634624-74-0	MitoTam iodide, hydriodide/CAS No.1634624-74-0 is a Tamoxifen derivative, an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology. MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells. MitoTam iodide, hydriodide causes apoptosis.	price>
R-R-1819	Rhosin hydrochloride CAS No.1281870-42-5	Rhosin hydrochloride/CAS No.1281870-42-5 is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability.	price>
R-R-1820	Thiocolchicine-d3 CAS No.1314417-95-2	Thiocolchicine-d3/CAS No.1314417-95-2 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.	price>
R-R-1821	Voreloxin Hydrochloride CAS No.175519-16-1	Voreloxin Hydrochloride/CAS No.175519-16-1 is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.	price>
R-R-1822	Jolkinolide B CAS No.37905-08-1	Jolkinolide B/CAS No.37905-08-1, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells.	price>
R-R-1823	Deoxypodophyllotoxin CAS No.19186-35-7	Deoxypodophyllotoxin (DPT)/CAS No.19186-35-7, a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and apoptosis. Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons.	price>
R-R-1824	PARP-1-IN-2 CAS No.684234-55-7	PARP-1-IN-2 (compound 11g)/CAS No.684234-55-7 is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis.	price>
R-R-1825	Myristoleic acid CAS No.544-64-9	Myristoleic acid/CAS No.544-64-9, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells.	price>

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