Product apis-apoptosis

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Catalog	name	Description	price
R-R-1794	Polygalacin D CAS No.66663-91-0	Polygalacin D (PGD)/CAS No.66663-91-0 is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis	price>
R-R-1795	Destruxin B CAS No.2503-26-6	Destruxin B/CAS No.2503-26-6, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.	price>
R-R-1796	DC260126 CAS No.346692-04-4	DC260126/CAS No.346692-04-4 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.	price>
R-R-1797	Fosinopril sodium CAS No.88889-14-9	Fosinopril Sodium/CAS No.88889-14-9 is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.	price>
R-R-1798	Vallesiachotamine CAS No.5523-37-5	Vallesiachotamine/CAS No.5523-37-5, a known monoterpene indole alkaloid, possesses anti-tumor activity.	price>
R-R-1799	Erbstatin CAS No.100827-28-9	Erbstatin/CAS No.100827-28-9, a EGFR kinase inhibitor, possesses antineoplastic effect.	price>
R-R-1800	MC4033 CAS No.28532-21-0	MC4033/CAS No.28532-21-0 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively. MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells.	price>
R-R-1801	Phenoxodiol CAS No.81267-65-4	Phenoxodiol (Idronoxil)/CAS No.81267-65-4, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner.	price>
R-R-1802	Valepotriate CAS No.18296-44-1	Valepotriate/CAS No.18296-44-1 can be isolated from Valeriana jatamansi Jones, has anti-epileptic and anti-cancer activities.	price>
R-R-1803	Ginkgolide B CAS No.15291-77-7	Ginkgolide B (BN-52021)/CAS No.15291-77-7, an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis.Ginkgolide B (BN-52021)/CAS No.15291-77-7, an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis.	price>

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